Methyl Pyrazolo[1,5-a]pyridine-2-carboxylate

Base Information

• Chemical Name: Methyl Pyrazolo[1,5-a]pyridine-2-carboxylate
• CAS No.: 151831-21-9
• Molecular Formula: C9H8N2O2
• Molecular Weight: 176.17
• Hs Code.: 2933990090
• Mol file: 151831-21-9.mol

Synonyms:Methyl Pyrazolo[1,5-a]pyridine-2-carboxylate

Chemical Property of Methyl Pyrazolo[1,5-a]pyridine-2-carboxylate

Chemical Property:

• Melting Point: 91-92 °C(Solv: methanol (67-56-1); ethyl acetate (141-78-6))
• PKA: 0.07±0.30(Predicted)
• PSA: 43.60000
• Density: 1.26±0.1 g/cm3(Predicted)
• LogP: 1.12090

Purity/Quality:

97% ^*data from raw suppliers

methylpyrazolo[1,5-a]pyridine-2-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Methyl Pyrazolo[1,5-a]pyridine-2-carboxylate

There total 5 articles about Methyl Pyrazolo[1,5-a]pyridine-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

(Z)-methyl 2-azido-3-(pyridin-2-yl)acrylate → methyl pyrazolo[1,5-a]pyridine-2-carboxylate (151831-21-9)

Guidance literature:

In toluene; at 220 ℃; under 19126.9 Torr; continuous flow reactor;

DOI:10.1039/c0cc04481d

Reference yield: 81.38%

methanol (67-56-1) + pyrazolo[1,5-a]pyridine-2-carboxylic acid (63237-88-7) → methyl pyrazolo[1,5-a]pyridine-2-carboxylate (151831-21-9)

Guidance literature:

With sulfuric acid; at 0 - 80 ℃; for 12h;

Reference yield: 67.0%

C9H8N4O2 → methyl pyrazolo[1,5-a]pyridine-2-carboxylate (151831-21-9)

Guidance literature:

In 1,3,5-trimethyl-benzene; at 160 - 185 ℃;

DOI:10.15227/orgsyn.084.0262

upstream raw materials:

pyridine-2-carbaldehyde

pyrazolo<1,5-a>pyridine-2,3-dicarboxylic acid dimethyl ester

methanol

pyrazolo[1,5-a]pyridine-2-carboxylic acid