3-AMINO-5-BROMO-BENZOFURAN-2-CARBOXYLIC ACID ETHYL ESTER

Base Information

• Chemical Name: 3-AMINO-5-BROMO-BENZOFURAN-2-CARBOXYLIC ACID ETHYL ESTER
• CAS No.: 330555-71-0
• Molecular Formula: C11H10BrNO3
• Molecular Weight: 284.11
• Hs Code.: 2932999099
• Mol file: 330555-71-0.mol

Synonyms:Ethyl 3-amino-5-bromobenzofuran-2-carboxylate; ethyl 3-amino-5-bromobenzo[d]furan-2-carboxylate; 3-Amino-5-bromo-benzofuran-2-carboxylic acid ethyl ester; ethyl 5-bromo-3-amino-2-benzofurancarboxylate

Chemical Property of 3-AMINO-5-BROMO-BENZOFURAN-2-CARBOXYLIC ACID ETHYL ESTER

Chemical Property:

• Melting Point: 155-157°
• PSA: 42.23000
• LogP: 1.74210

Purity/Quality:

97% ^*data from raw suppliers

Ethyl 3-amino-5-bromo-1-benzofuran-2-carboxylate >95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-AMINO-5-BROMO-BENZOFURAN-2-CARBOXYLIC ACID ETHYL ESTER

There total 7 articles about 3-AMINO-5-BROMO-BENZOFURAN-2-CARBOXYLIC ACID ETHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

5-bromo-2-hydroxybenzonitrile (40530-18-5) + ethyl bromoacetate (105-36-2) → ethyl 3-amino-5-bromo-1-benzofuran-2-carboxylate (330555-71-0)

Guidance literature:

With sodium carbonate; In acetone; for 24h; Reflux;

DOI:10.1016/j.bmcl.2013.02.021

Reference yield: 76.66%

(4-bromo-2-cyanophenoxy)acetic acid ethyl ester (328009-03-6) → ethyl 3-amino-5-bromo-1-benzofuran-2-carboxylate (330555-71-0)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide;

Reference yield:

5-bromo-2-hydroxybenzonitrile (40530-18-5) → ethyl 3-amino-5-bromo-1-benzofuran-2-carboxylate (330555-71-0)

Guidance literature:

Multi-step reaction with 2 steps

1: K₂CO₃

2: NaH

With sodium hydride; potassium carbonate;

DOI:10.1039/b307468d

upstream raw materials:

(4-bromo-2-cyanophenoxy)acetic acid ethyl ester

salicylonitrile

ethyl 2-(2-cyanophenoxy)acetate

5-bromo-2-hydroxybenzonitrile

Downstream raw materials:

C₁₇H₁₄BrN₃O₂

C₁₇H₁₃BrClN₃O₂

C₁₇H₁₃Br₂N₃O₂

C₁₈H₁₆BrN₃O₃

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