328009-03-6

Upstream product

• 40530-18-5 5-bromo-2-hydroxybenzonitrile 
• 105-36-2 ethyl bromoacetate 
• 611-20-1 salicylonitrile 
• 105-39-5 chloroacetic acid ethyl ester 
• 1761-61-1 5-bromosalicyclaldehyde 
• 39786-34-0 ethyl 2-(2-cyanophenoxy)acetate 

Downstream Products

• 636992-58-0 (E)-[2-cyano-4-(2-diethylcarbamoyl-1-methylvinyl)phenoxy]acetic acid ethyl ester 
• 1277185-69-9 C₁₇H₁₄BrN₃O₂ 
• 1277185-70-2 C₁₇H₁₃BrClN₃O₂ 
• 1277185-71-3 C₁₇H₁₃Br₂N₃O₂ 
• 1277185-72-4 C₁₈H₁₆BrN₃O₃ 
• 1277185-73-5 C₁₇H₁₂BrCl₂N₃O₂ 
• 1277185-74-6 C₁₉H₁₂BrN₃O₃ 
• 1277185-75-7 C₁₉H₁₁BrClN₃O₃ 
• 1277185-76-8 C₁₉H₁₁Br₂N₃O₃ 
• 1277185-77-9 C₂₀H₁₄BrN₃O₄ 
• 1277185-78-0 C₁₉H₁₀BrCl₂N₃O₃ 
• 330555-71-0 ethyl 3-amino-5-bromo-1-benzofuran-2-carboxylate 

Relevant academic research and scientific papers

Identification and characterization of a novel HIV-1 nucleotide-competing reverse transcriptase inhibitor series

Several groups have recently reported on the identification of nucleotide-competing reverse transcriptase inhibitors (NcRTIs), a new class of RT inhibitors. NcRTIs reversibly inhibit binding of the incoming nucleotide to the RT active site but do not act

CONDENSED TRICLYCLIC COMPOUNDS AS INHIBITORS OF HIV REPLICATION

Compounds of formula (I) and pharmaceutical compositions thereof: wherein A1 A2 and A3 are each independently selected from the group consisting of N and CR3, wherein R1 is an optionally substituted heterocyclyl or an optionally substituted -(C1-6)alkyl-heterocyclyl, R2 is an optionally substituted aryl or an optionally subsisted heteroaryl, R4 is an optionally substituted aryl, an optionally substituted heterocyclyl or an optionally substituted heteroaryl, useful as an inbitor of HIV replication.

Synthesis of some pyrazole incorporated benzofurans and their antiinflammatory activity

The reaction of 5-bromosalicylaldehyde 1 with hydroxylamine hydrochloride gave 5-bromosalicylonitrile 2 which upon condensation with ethyl chloroacetate followed by cyclization gave ethyl 3-amino-5-bromo-1-benzofuran-2-carboxylate 4. The compound 4 on treatment with hydrazine hydrate in ethanol gave 3-amino-5-bromo-1-benzofuran-2-carbohydrazide 5 which further on reaction with various substituted acetophenones in abs ethanol in presence of catalytic quantity of hydrochloric acid furnished corresponding hydrazones 6a-e. The title compounds 7a-e were synthesized by the reaction of 6a-e with Vilsmerier-Haack reagent. The structures of all synthesized compounds were established using analytical and spectral data. 6a-e and 7a-e have been evaluated for antiinflammatory activities.

Synthesis and anti-microbial activities of oxadiazoles, thiadiazoles and triazoles containing 5-bromo-3-amino benzofuran nucleus from 5-bromosalicylonitrile

5-Bromosalicylonitrile 2 has been prepared from 5-Bromosalicylladehyde 1 and hydroxylamine hydrochloride, which on further treatment with ethyl chloroacetate gave ethyl 5-bromo-3-amino-2-benzofurancarboxylate 4. The resulting compound 4 was treated with hydrazine hydrate in boiling ethanol gave the hydrazide compound 5. The resulting hydrazide was reacted with substituted aryl isothiocyanates and offered thiosemicarbazide compounds 6-9. 5Bromo-3-amino-2+--benzofurothiosemicarbazides underwent cyclization with different reagents under different reaction conditions to furnish benzofuran derivatives possessing oxadiazoles, triazoles and thiadiazoles 10-21 respectively. The structures of all the compounds have been assigned by elemental analysis and spectral studies. The synthesized compounds were screened for their antimicrobial and antifungal activities.

Syntheses of 3-acetoacetylaminobenzo[b]furan derivatives having cysteinyl leukotriene 2 receptor antagonistic activity

Novel 3-acetoacetylaminobenzo[b]furan derivatives having a modified triene system at the 3-position were synthesized starting with 3-aminobenzo[b]furans. The enol isomers, 3-[(3-hydroxybul-2-enonyl)amino]benzo[b]furans (1), of the 3-acetoacetylaminobenzo[b]furans were obtained as stable isomers owing to formation of a hydrogen bonding between the enol hydroxyl group and the amidocarbonyl group. The planarity of the C-2 substituent through the C-3 side chain suggested the existence of a modified conjugational triene system in the enol compound. Cysteinyl leukotriene 1 and 2 receptor antagonistic activities for these compounds were evaluated. 2-(4-Cyanobenzoyl or ethoxycarbonyl)-3-[(2-cyano-3-hydroxybut-2-enonyl)amino]benzo[e]furans (15g, 15o, 15u) were moderately active.

Preparation of 3-acetoacetylaminobenzo[b]furan derivatives with cysteinyl leukotriene receptor 2 antagonistic activity.

Novel 3-acetoacetylaminobenzo[b]furan derivatives with a modified triene system at the 3-position were prepared through acylation of the 3-aminobenzo[b]furans with 5-methylisoxazole-4-carboxylic acid chloride followed by basic cleavage of the isoxazole ring and several of these compounds showed moderate cysteinyl leukotriene receptor 2 antagonistic activity.