N-Trityl-L-glutamic acid

Base Information

• Chemical Name: N-Trityl-L-glutamic acid
• CAS No.: 80514-73-4
• Molecular Formula: C24H23NO4
• Molecular Weight: 389.44
• DSSTox Substance ID: DTXSID20456787
• Wikidata: Q82279357
• Mol file: 80514-73-4.mol

Synonyms:N-TRITYL-L-GLUTAMIC ACID;80514-73-4;(2S)-2-(tritylamino)pentanedioic Acid;N-TRITYL-L-GLUTAMICACID;SCHEMBL4627986;DTXSID20456787;(S)-2-(Tritylamino)pentanedioic acid;AKOS025212537

Chemical Property of N-Trityl-L-glutamic acid

Chemical Property:

• Boiling Point: 575.5±50.0 °C(Predicted)
• PKA: 2.02±0.10(Predicted)
• Density: 1.241±0.06 g/cm3(Predicted)
• XLogP3: 1.7
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 9
• Exact Mass: 389.16270821
• Heavy Atom Count: 29
• Complexity: 485

Purity/Quality:

85.0-99.8% ^*data from raw suppliers

N-TRITYL-L-GLUTAMIC ACID 98.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C(C2=CC=CC=C2)(C3=CC=CC=C3)NC(CCC(=O)O)C(=O)O
• Isomeric SMILES: C1=CC=C(C=C1)C(C2=CC=CC=C2)(C3=CC=CC=C3)N[C@@H](CCC(=O)O)C(=O)O

Technology Process of N-Trityl-L-glutamic acid

There total 5 articles about N-Trityl-L-glutamic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-trityl-L-glutamic acid 5-methyl ester (55878-80-3) → N-trityl-L-glutamic acid (80514-73-4)

Guidance literature:

With sodium hydroxide; Hydrolysis;

Reference yield:

dibenzyl N-trityl-(S)-glutamate (73469-43-9) → N-trityl-L-glutamic acid (80514-73-4)

Guidance literature:

With palladium; ethyl acetate; triethylamine; Hydrogenation;

Reference yield:

L-glutamic acid (56-86-0,21675-62-7,23009-64-5,25104-13-6,84960-48-5,25513-46-6) + trityl chloride (76-83-5) → N-trityl-L-glutamic acid (80514-73-4)

Guidance literature:

With triethylamine;

upstream raw materials:

N-trityl-L-glutamic acid 5-methyl ester

dibenzyl N-trityl-(S)-glutamate

L-glutamic acid

trityl chloride

Downstream raw materials:

(L)-Trt-Glp-OH

(S)-2-L-γ-glutamylamino-3-((S)-2-methylene-cyclopropyl)-propionic acid

N-(γ-L-glutamyl)ethanolamine