Cyclohexaneacetic acid, 4-[4-(hydroxyMethyl)phenyl]-, ethyl ester, trans-

Base Information

Chemical Name:Cyclohexaneacetic acid, 4-[4-(hydroxyMethyl)phenyl]-, ethyl ester, trans-
CAS No.:1031336-84-1
Molecular Formula:C17H24O3
Molecular Weight:276.376
Hs Code.:
Mol file:1031336-84-1.mol

Synonyms:trans-ethyl 2-4-((4-(hydroxymethyl)phenyl)cyclohexyl)acetate;cyclohexane-trans-1,2-dicarboxylic acid dimethyl ester;trans-1,2-Cyclohexanedicarboxylic Acid Dimethyl Ester;Dimethyl trans-1,2-Cyclohexanedicarboxylate;trans ethyl 2-(4-(4-(cyanomethyl)phenyl)cyclohexyl)acetate;(+-)-trans-Cyclohexan-1,2-dicarbonsaeure-dimethylester;trans dimethyl cyclohexane-1,2-dicarboxylate;dimethyl cyclohexane-trans-1,2-dicarboxylate;trans-dimethyl 1,2-cyclohexanedicarboxylate;(+-)-trans-cyclohexane-1,2-dicarboxylic acid dimethyl ester;

Suppliers and Price of Cyclohexaneacetic acid, 4-[4-(hydroxyMethyl)phenyl]-, ethyl ester, trans-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemicals and raw materials
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Total 4 raw suppliers

Chemical Property of Cyclohexaneacetic acid, 4-[4-(hydroxyMethyl)phenyl]-, ethyl ester, trans-

Chemical Property:

Boiling Point:410.9±20.0 °C(Predicted)
PKA:14.46±0.10(Predicted)
PSA：46.53000
Density:1.069±0.06 g/cm3(Predicted)
LogP:3.40590

Purity/Quality:: ≥95% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

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Technology Process of Cyclohexaneacetic acid, 4-[4-(hydroxyMethyl)phenyl]-, ethyl ester, trans-

There total 6 articles about Cyclohexaneacetic acid, 4-[4-(hydroxyMethyl)phenyl]-, ethyl ester, trans- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.1%

: 1031336-68-1
trans ethyl 2-(4-(4-(chlorocarbonyl)phenyl)cyclohexyl)acetate

: 1031336-84-1
trans-ethyl 2-4-((4-(hydroxymethyl)phenyl)cyclohexyl)acetate

Guidance literature:: With 5%-palladium/activated carbon; hydrogen; triethylamine; In tetrahydrofuran; at 20 ℃; for 18h; under 2068.65 Torr;
DOI:10.1021/jm201524g

Reference yield:

: 1031336-66-9
trans-ethyl 2-4-((4-(hydroxymethyl)phenyl)cyclohexyl)acetate

: 1031336-84-1
trans-ethyl 2-4-((4-(hydroxymethyl)phenyl)cyclohexyl)acetate

Guidance literature:: Multi-step reaction with 2 steps

1.1: aluminum (III) chloride / n-heptane; dichloromethane / 0.75 h / -5 - 10 °C / Inert atmosphere

1.2: 0.5 h / -5 - 20 °C / Inert atmosphere

2.1: 5%-palladium/activated carbon; hydrogen; triethylamine / tetrahydrofuran / 18 h / 20 °C / 2068.65 Torr

With aluminum (III) chloride; 5%-palladium/activated carbon; hydrogen; triethylamine; In tetrahydrofuran; n-heptane; dichloromethane;
DOI:10.1021/jm201524g

Reference yield:

: 411238-92-1
ethyl 2-(4-phenylcyclohexyl)acetate

: 1031336-84-1
trans-ethyl 2-4-((4-(hydroxymethyl)phenyl)cyclohexyl)acetate

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium hydroxide / ethanol; water / 7 h / 50 °C / Inert atmosphere

2.1: hydrogenchloride / water; ethyl acetate / Inert atmosphere

2.2: Reflux; Inert atmosphere

3.1: aluminum (III) chloride / n-heptane; dichloromethane / 0.75 h / -5 - 10 °C / Inert atmosphere

3.2: 0.5 h / -5 - 20 °C / Inert atmosphere

4.1: 5%-palladium/activated carbon; hydrogen; triethylamine / tetrahydrofuran / 18 h / 20 °C / 2068.65 Torr

With hydrogenchloride; aluminum (III) chloride; 5%-palladium/activated carbon; hydrogen; triethylamine; lithium hydroxide; In tetrahydrofuran; ethanol; n-heptane; dichloromethane; water; ethyl acetate;
DOI:10.1021/jm201524g