Technology Process of Cyclohexaneacetic acid, 4-[4-(chlorocarbonyl)phenyl]-, ethyl ester, trans-
There total 5 articles about Cyclohexaneacetic acid, 4-[4-(chlorocarbonyl)phenyl]-, ethyl ester, trans- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
oxalyl dichloride; trans-ethyl 2-4-((4-(hydroxymethyl)phenyl)cyclohexyl)acetate;
With
aluminum (III) chloride;
In
n-heptane; dichloromethane;
at -5 - 10 ℃;
for 0.75h;
Inert atmosphere;
With
calcium chloride;
In
n-heptane; dichloromethane; water;
at -5 - 20 ℃;
for 0.5h;
Inert atmosphere;
DOI:10.1021/jm201524g
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: lithium hydroxide / ethanol; water / 7 h / 50 °C / Inert atmosphere
2.1: hydrogenchloride / water; ethyl acetate / Inert atmosphere
2.2: Reflux; Inert atmosphere
3.1: aluminum (III) chloride / n-heptane; dichloromethane / 0.75 h / -5 - 10 °C / Inert atmosphere
3.2: 0.5 h / -5 - 20 °C / Inert atmosphere
With
hydrogenchloride; aluminum (III) chloride; lithium hydroxide;
In
ethanol; n-heptane; dichloromethane; water; ethyl acetate;
DOI:10.1021/jm201524g
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: hydrogenchloride / water; ethyl acetate / Inert atmosphere
1.2: Reflux; Inert atmosphere
2.1: aluminum (III) chloride / n-heptane; dichloromethane / 0.75 h / -5 - 10 °C / Inert atmosphere
2.2: 0.5 h / -5 - 20 °C / Inert atmosphere
With
hydrogenchloride; aluminum (III) chloride;
In
n-heptane; dichloromethane; water; ethyl acetate;
DOI:10.1021/jm201524g
