Technology Process of trans-4-[4-(7-Aminopyrazolo[1,5-a]pyrimidin-6-yl)phenyl]cyclohexaneacetic acid
There total 10 articles about trans-4-[4-(7-Aminopyrazolo[1,5-a]pyrimidin-6-yl)phenyl]cyclohexaneacetic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
C22H26N4O2;
With
sodium hydroxide;
In
tetrahydrofuran; methanol;
at 50 ℃;
for 1.25h;
Inert atmosphere;
With
hydrogenchloride;
In
tetrahydrofuran; methanol; water;
at 50 ℃;
Inert atmosphere;
DOI:10.1021/jm201524g
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: aluminum (III) chloride / n-heptane; dichloromethane / 0.75 h / -5 - 10 °C / Inert atmosphere
1.2: 0.5 h / -5 - 20 °C / Inert atmosphere
2.1: 5%-palladium/activated carbon; hydrogen; triethylamine / tetrahydrofuran / 18 h / 20 °C / 2068.65 Torr
3.1: hydrogen bromide; acetic acid / water / 1.5 h / Inert atmosphere
4.1: water; acetonitrile / 6.25 h / 40 - 50 °C / Inert atmosphere
5.1: toluene / 70 °C / Inert atmosphere
6.1: acetic acid / toluene; acetonitrile / 21 h / 75 °C / Inert atmosphere
7.1: sodium hydroxide / tetrahydrofuran; methanol / 1.25 h / 50 °C / Inert atmosphere
7.2: 50 °C / Inert atmosphere
With
aluminum (III) chloride; 5%-palladium/activated carbon; hydrogen bromide; hydrogen; acetic acid; triethylamine; sodium hydroxide;
In
tetrahydrofuran; methanol; n-heptane; dichloromethane; water; toluene; acetonitrile;
DOI:10.1021/jm201524g
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: hydrogenchloride / water; ethyl acetate / Inert atmosphere
1.2: Reflux; Inert atmosphere
2.1: aluminum (III) chloride / n-heptane; dichloromethane / 0.75 h / -5 - 10 °C / Inert atmosphere
2.2: 0.5 h / -5 - 20 °C / Inert atmosphere
3.1: 5%-palladium/activated carbon; hydrogen; triethylamine / tetrahydrofuran / 18 h / 20 °C / 2068.65 Torr
4.1: hydrogen bromide; acetic acid / water / 1.5 h / Inert atmosphere
5.1: water; acetonitrile / 6.25 h / 40 - 50 °C / Inert atmosphere
6.1: toluene / 70 °C / Inert atmosphere
7.1: acetic acid / toluene; acetonitrile / 21 h / 75 °C / Inert atmosphere
8.1: sodium hydroxide / tetrahydrofuran; methanol / 1.25 h / 50 °C / Inert atmosphere
8.2: 50 °C / Inert atmosphere
With
hydrogenchloride; aluminum (III) chloride; 5%-palladium/activated carbon; hydrogen bromide; hydrogen; acetic acid; triethylamine; sodium hydroxide;
In
tetrahydrofuran; methanol; n-heptane; dichloromethane; water; ethyl acetate; toluene; acetonitrile;
DOI:10.1021/jm201524g
