Lazabemide

Base Information

Chemical Name:Lazabemide
CAS No.:103878-84-8
Molecular Formula:C₈H₁₀ClN₃O
Molecular Weight:199.64
Hs Code.:
UNII:420HD787N9
DSSTox Substance ID:DTXSID2048294
Nikkaji Number:J324.183A
Wikipedia:Lazabemide
Wikidata:Q6505756
NCI Thesaurus Code:C80964
Pharos Ligand ID:TU4F1FX26P3A
ChEMBL ID:CHEMBL279390
Mol file:103878-84-8.mol

Synonyms:lazabemide;Ro 19-6327;Ro-19-6327

Suppliers and Price of Lazabemide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
Lazabemide hydrochloride
10mg
$ 366.00

Tocris
Lazabemidehydrochloride ≥98%(HPLC)
50
$ 521.00

Tocris
Lazabemidehydrochloride ≥98%(HPLC)
10
$ 129.00

Sigma-Aldrich
Lazabemide hydrate ≥97% (HPLC)
10mg
$ 81.50

Sigma-Aldrich
Lazabemide hydrate ≥97% (HPLC)
50mg
$ 315.00

DC Chemicals
Lazabemide >98%
250 mg
$ 400.00

CSNpharm
Lazabemide
25mg
$ 101.00

CSNpharm
Lazabemide
50mg
$ 192.00

CSNpharm
Lazabemide
10mg
$ 48.00

ChemScene
Lazabemide 99.76%
10mg
$ 60.00

Total 23 raw suppliers

Chemical Property of Lazabemide

Chemical Property:

Vapor Pressure:1.59E-06mmHg at 25°C
Refractive Index:1.571
Boiling Point:397.4 °C at 760 mmHg
PKA:12.90±0.46(Predicted)
Flash Point:194.2 °C
PSA：68.01000
Density:1.286 g/cm³
LogP:1.51470
Storage Temp.:room temp
Solubility.:DMSO: ≥22mg/mL
XLogP3:0.2
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:199.0512396
Heavy Atom Count:13
Complexity:177

Purity/Quality:

97% ^*data from raw suppliers

Lazabemide hydrochloride ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xn
Hazard Codes:Xn
Statements: 22-36
Safety Statements: 26

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC(=NC=C1Cl)C(=O)NCCN
Uses Lazabemide hydrate may be used in cell signaling studies.

Technology Process of Lazabemide

There total 4 articles about Lazabemide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.1%

: 128073-03-0
4-chloronicotinoyl chloride

: 107-15-3,85404-18-8
ethylenediamine

: 103878-84-8
lazabemide

Guidance literature:: In dichloromethane; water; at 0 - 10 ℃;
DOI:10.1016/j.bmc.2018.08.024

Reference yield: 89.0%

: 943621-63-4
2-(5-chloropyridine-2-yl)-1H-imidazoline

: 103878-84-8
lazabemide

Guidance literature:: With sodium hydroxide; water; at 100 ℃; for 1.5 - 3h; Product distribution / selectivity; Heating / reflux;

Reference yield:

: 86873-60-1
5-chloropicolinic acid

: 103878-84-8
lazabemide

Guidance literature:: Multi-step reaction with 2 steps

1: N,N-dimethyl-formamide; thionyl chloride / dichloromethane; water / 8 h / Reflux

2: dichloromethane; water / 0 - 10 °C

With thionyl chloride; N,N-dimethyl-formamide; In dichloromethane; water;
DOI:10.1016/j.bmc.2018.08.024