128073-03-0

Basic information

• Product Name: 2-Pyridinecarbonyl chloride, 5-chloro- (9CI)
• Synonyms: 2-Pyridinecarbonyl chloride, 5-chloro- (9CI);5-Chloro-2-Pyridinecarbonylchloride;5-chloropyridine-2-carbonyl chloride;2-Pyridinecarbonyl chloride, 5-chloro-;5-Chloropicolinoyl chloride
• CAS NO: 128073-03-0
• Molecular Formula: C₆H₃Cl₂NO
• Molecular Weight: 176.00012
• Product Categories: ACIDHALIDE
• Mol File: 128073-03-0.mol
• Article Data: 19

Chemical Properties

• Boiling Point: 220.761 °C at 760 mmHg
• Flash Point: 87.314 °C
• Appearance: /
• Density: 1.454 g/cm³
• CAS DataBase Reference: 2-Pyridinecarbonyl chloride, 5-chloro- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Pyridinecarbonyl chloride, 5-chloro- (9CI)(128073-03-0)
• EPA Substance Registry System: 2-Pyridinecarbonyl chloride, 5-chloro- (9CI)(128073-03-0)

Safety Data

• Hazardous Substances Data: 128073-03-0(Hazardous Substances Data)

Usage

General Description

2-Pyridinecarbonyl chloride, 5-chloro- (9CI) is a chemical compound with the molecular formula C6H4ClNO. It is a derivative of pyridine and is commonly used in organic synthesis as a versatile building block. 2-Pyridinecarbonyl chloride, 5-chloro- (9CI) is a reactive intermediate in the production of pharmaceuticals, agrochemicals, and other fine chemicals. It is also utilized in the manufacturing of dyes and pigments. 2-Pyridinecarbonyl chloride, 5-chloro- (9CI) is a valuable reagent in the pharmaceutical industry for the synthesis of various drugs and medications.

Upstream product

• 858844-85-6 1,3-bis(6-methylpyridin-3-yl)urea 
• 70788-54-4 2,3,4-trichloro-6-(trichloromethyl)pyridine 
• 1199-48-0 4,5-dichloro-2-(trichloromethyl)pyridine 
• 247077-42-5 (6-methyl-[3]pyridyl)-carbamic acid ethyl ester 
• 64038-04-6 6-methyl-nicotinoyl azide 
• 197079-25-7 6-methylpyridine-3-carbohydrazide 
• 21684-59-3 ethyl 6-methylnicotinate 
• 6960-22-1 6-methylnicotinamide 
• 72093-07-3 2-methyl-5-chloropyridine 
• 80287-53-2 5-Amino-2-methylpyridine 
• 86873-60-1 5-chloropicolinic acid 

Downstream Products

• 132308-19-1 methyl 5-chloropyridine-2-carboxylate 
• 1113049-94-7 C₂₆H₂₁ClF₄N₆O₄ 
• 1113050-22-8 C₂₇H₂₁ClF₄N₆O₅ 
• 342601-76-7 5-chloro-N-methoxy-N-methylpicolinamide 
• 103878-84-8 lazabemide 
• 10177-24-9 5-chloro-pyridin-2-ylmethyl chloride 
• 1271948-76-5 (S)-N-(3-(2-amino-4-methyl-5,6-dihydro-4H-1,3-thiazin-4-yl)-4-fluorophenyl)-5-chloropicolinamide 
• 1271949-32-6 5-chloro-pyridine-2-carboxylic acid [3-((R)-2-amino-4-methyl-5,6-dihydro-4H-[1,3]thiazin-4-yl)-4-fluoro-phenyl]-amide 
• 1271949-56-4 5-chloro-pyridine-2-carboxylic acid [3-((E)-3-carbamimidoylsulfanyl-1-methyl-propenyl)-4-fluoro-phenyl]-amide hydrochloride 
• 1271949-54-2 5-chloro-pyridine-2-carboxylic acid [4-fluoro-3-(1-hydroxy-1-methyl-allyl)-phenyl]-amide 
• 935999-02-3 5-chloro-pyridine-2-carboxylic acid [3-((S)-2-amino-4-methyl-5,6-dihydro-4H-[1,3]thiazin-4-yl)-4-fluoro-phenyl]-amide 
• 1271949-52-0 5-chloro-pyridine-2-carboxylic acid (3-acetyl-4-fluoro-phenyl)-amide 
• 929214-89-1 methyl 2-{[(5-chloropyridin-2-yl)carbonyl]amino}-4-methylbenzoate 
• 1163694-03-8 C₂₆H₂₂ClF₃N₆O₅ 

Relevant articles and documents

Design and Discovery of Novel Antifungal Quinoline Derivatives with Acylhydrazide as a Promising Pharmacophore

Inspired by natural 2-quinolinecarboxylic acid derivatives, a series of quinoline compounds containing acylhydrazine, acylhydrazone, sulfonylhydrazine, oxadiazole, thiadiazole, or triazole moieties were synthesized and evaluated for their fungicidal activity. Most of these compounds exhibited excellent fungicidal activity in vitro. Significantly, compound 2e displayed the superior in vitro antifungal activity against Sclerotinia sclerotiorum, Rhizoctonia solani, Botrytis cinerea, and Fusarium graminearum with the EC50 values of 0.39, 0.46, 0.19, and 0.18 μg/mL, respectively, and were more potent than those of carbendazim (EC50, 0.68, 0.14, >100, and 0.65 μg/mL, respectively). Moreover, compound 2e could inhibit spore germination of F. graminearum. Preliminary mechanistic studies showed that compound 2e could cause abnormal morphology of cell walls and vacuoles, loss of mitochondrion, increases in membrane permeability, and release of cellular contents. These results indicate that compound 2e displayed superior fungicidal activities and could be a potential fungicidal candidate against plant fungal diseases.

Synthetic method of novel monoamine oxidase inhibitor (malabemide)

The invention discloses a synthetic method of a novel monoamine oxidase inhibitor (malabemide). According to the synthetic method, 5-chloro-2-pyridine carboxylic acid is taken as the primary raw material, after acyl-chlorination reactions, 5-chloro-2-pyridine formyl chloride is generated; then after amidation reactions, 5-chloro-N-(2-hydroxyethyl)-2-pyridine formyl chloride is generated, and finally 5-chloro-N-(2-hydroxyethyl)-2-pyridine formyl chloride and morpholine carry out condensation reactions to generate malabemide. Ethanolamine, 5-chloro-2-pyridine carboxylic acid, and morpholine aretaken as the main raw materials to prepare the novel monoamine oxidase inhibitor (malabemide); and the raw materials are easily available. The synthetic method has the advantages of simple operation,high product purity, and high yield, and is suitable for industrial production.

New compound Malabemide, preparation method and uses thereof

The invention discloses a new compound Malabemide with a molecule formula represented by a formula h, a preparation method and pharmaceutical applications thereof, wherein ethanolamine and 5-chloro-2-pyridinecarboxylic acid are used as starting raw materials, corresponding intermediates 2-bromoethylamine hydrobromide and 5-chloro-2-pyridinecarbonyl chloride are respectively synthesized, and are subjected to a reaction to generate 5-chloro-N-(2-bromoethyl)-2-pyridinecarboxamide, and the 5-chloro-N-(2-bromoethyl)-2-pyridinecarboxamide and morpholine are subjected to condensation to generate Malabemide h. According to the present invention, the preparation method has characteristics of easily available raw materials, simple operation, good product purity and high yield, and is suitable for industrial production. The formula h is defined in the specification.