(S)-tert-butyl 1-(5-fluoropyridin-2-yl)ethylcarbaMate

Base Information

Chemical Name:(S)-tert-butyl 1-(5-fluoropyridin-2-yl)ethylcarbaMate
CAS No.:905587-16-8
Molecular Formula:C12H17FN2O2
Molecular Weight:240.27
Hs Code.:2933399090
Mol file:905587-16-8.mol

Synonyms:Carbamic acid, [(1S)-1-(5-fluoro-2-pyridinyl)ethyl]-, 1,1-dimethylethyl ester;

Suppliers and Price of (S)-tert-butyl 1-(5-fluoropyridin-2-yl)ethylcarbaMate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
(S)-tert-Butyl(1-(5-fluoropyridin-2-yl)ethyl)carbamate 95+%
1g
$ 614.00

Chemenu
(S)-tert-Butyl1-(5-fluoropyridin-2-yl)ethylcarbamate 95%
1g
$ 580.00

American Custom Chemicals Corporation
(S)-TERT-BUTYL (1-(5-FLUOROPYRIDIN-2-YL)ETHYL)CARBAMATE 95.00%
1G
$ 1274.70

American Custom Chemicals Corporation
(S)-TERT-BUTYL (1-(5-FLUOROPYRIDIN-2-YL)ETHYL)CARBAMATE 95.00%
5MG
$ 504.34

Alichem
(S)-tert-Butyl(1-(5-fluoropyridin-2-yl)ethyl)carbamate
1g
$ 510.00

Total 13 raw suppliers

Chemical Property of (S)-tert-butyl 1-(5-fluoropyridin-2-yl)ethylcarbaMate

Chemical Property:

Boiling Point:324.8±32.0 °C(Predicted)
PKA:11.26±0.46(Predicted)
PSA：51.22000
Density:1.115±0.06 g/cm3(Predicted)
LogP:3.19730
Storage Temp.:2-8°C

Purity/Quality:

99% ^*data from raw suppliers

(S)-tert-Butyl(1-(5-fluoropyridin-2-yl)ethyl)carbamate 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of (S)-tert-butyl 1-(5-fluoropyridin-2-yl)ethylcarbaMate

There total 7 articles about (S)-tert-butyl 1-(5-fluoropyridin-2-yl)ethylcarbaMate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 905587-17-9
(S)-N-(1-(5-fluoropyridin-2-yl)ethyl)acetamide

: 24424-99-5
di-tert-butyl dicarbonate

: 905587-16-8
(S)-tert-butyl-1-(5-fluoropyridin-2-yl)ethylcarbamate

Guidance literature:: (S)-N-(1-(5-fluoropyridin-2-yl)ethyl)acetamide; di-tert-butyl dicarbonate; With dmap; In tetrahydrofuran; at 50 ℃; for 20h;

With lithium hydroxide; water; In tetrahydrofuran; at 20 ℃; for 5h;

Reference yield:

: C₁₄H₁₉FN₂O₃

: 905587-16-8
(S)-tert-butyl-1-(5-fluoropyridin-2-yl)ethylcarbamate

Guidance literature:: With lithium hydroxide; water; In tetrahydrofuran; at 18 - 25 ℃; for 5h;

Reference yield:

: 327056-62-2
5-fluoropicolinonitrile

: 905587-16-8
(S)-tert-butyl-1-(5-fluoropyridin-2-yl)ethylcarbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: tetrahydrofuran; diethyl ether / 0.5 h / 0 °C

1.2: 8 h / 0 - 25 °C

2.1: hydrogen / (+)-1,2-bis-((2S,5S)-2,5-diethylphospholano)benzene(cyclooctadiene)rhodium(I) trifluoromethanesulfonate / methanol / 7 h / 18 - 25 °C / 6205.94 - 7757.43 Torr

3.1: dmap / tetrahydrofuran / 20 h / 50 °C

3.2: 5 h / 18 - 25 °C

With hydrogen; dmap; (+)-1,2-bis-((2S,5S)-2,5-diethylphospholano)benzene(cyclooctadiene)rhodium(I) trifluoromethanesulfonate; In tetrahydrofuran; methanol; diethyl ether;