cis-8-Methoxy-1,3-diazaspiro[4.5]decane-2,4-dione

Base Information

• Chemical Name: cis-8-Methoxy-1,3-diazaspiro[4.5]decane-2,4-dione
• CAS No.: 387825-48-1
• Molecular Formula: C9H14N2O3
• Molecular Weight: 198.22
• DSSTox Substance ID: DTXSID10459409
• Mol file: 387825-48-1.mol

Synonyms:cis-8-Methoxy-1,3-diazaspiro[4.5]decane-2,4-dione;387825-48-1;8-methoxy-1,3-diazaspiro[4.5]decane-2,4-dione;cis 8-Methoxy-1,3-diazaspiro(4.5)decane-2,4-dione sodium salt;cis 8-methoxy-1,3-diazaspiro[4.5]decane-2,4-dione sodium salt;SCHEMBL3540442;DTXSID10459409;AKOS015999661;EC 929-513-6;A873781;(5S,8S)-8-METHOXY-1,3-DIAZASPIRO[4.5]DECANE-2,4-DIONE

Chemical Property of cis-8-Methoxy-1,3-diazaspiro[4.5]decane-2,4-dione

Chemical Property:

• PSA: 74.41000
• LogP: 0.06950
• Storage Temp.: 2-8°C
• XLogP3: -0.1
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 198.10044231
• Heavy Atom Count: 14
• Complexity: 269

Purity/Quality:

97% ^*data from raw suppliers

cis-8-Methoxy-1,3-diazaspiro[4.5]decane-2,4-dione 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: COC1CCC2(CC1)C(=O)NC(=O)N2

Technology Process of cis-8-Methoxy-1,3-diazaspiro[4.5]decane-2,4-dione

There total 13 articles about cis-8-Methoxy-1,3-diazaspiro[4.5]decane-2,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

1-amino-4-methoxycyclohexane (4342-46-5) + carbon monoxide (201230-82-2) + formamide (77287-34-4,77287-35-5,60100-09-6) → cis-8-methoxy-1,3-diazaspiro[4,5]-decane-2,4-dione (387825-48-1)

Guidance literature:

formamide; for 0.166667h; Autoclave;

1-amino-4-methoxycyclohexane; carbon monoxide; at 130 ℃; for 20h; under 1500.15 Torr; Temperature;

Reference yield: 75.0%

sodium cyanide (773837-37-9) + 4-methoxycyclohexanone (13482-23-0) + ammonium carbonate (506-87-6,6721-33-1,10361-29-2) → cis-8-methoxy-1,3-diazaspiro[4,5]-decane-2,4-dione (387825-48-1)

Guidance literature:

ammonium carbonate; In water; for 0.166667h;

sodium cyanide; In water; for 0.5h;

4-methoxycyclohexanone; In water; at 50 ℃; for 20h;

Reference yield: 44.6%

sodium cyanide (773837-37-9) + 4-methoxycyclohexanone (13482-23-0) + ammonium carbonate (506-87-6,6721-33-1,10361-29-2) → cis-8-methoxy-1,3-diazaspiro[4.5]decane-2,4-dione (387825-48-1)

Guidance literature:

In water; at 50 ℃; for 15h;

DOI:10.1134/S1070428020100176

upstream raw materials:

cis-8-methoxy-1,3-diazaspiro[4.5]decane-2,4-dione

1-amino-4-methoxycyclohexane

carbon monoxide

formamide

Downstream raw materials:

cis-1-amino-4-methoxycyclohexane-1-carboxylic acid

methyl-cis-1-amino-4-methoxy-cyclohexanecarboxylate

spirotetramat

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