(R)-1-(3,4-Difluorophenyl)propan-1-amine hydrochloride

Base Information

Chemical Name:(R)-1-(3,4-Difluorophenyl)propan-1-amine hydrochloride
CAS No.:847448-32-2
Molecular Formula:C9H11F2N
Molecular Weight:171.19
Hs Code.:2921499090
European Community (EC) Number:696-490-4
Mol file:847448-32-2.mol

Synonyms:(R)-1-(3,4-Difluorophenyl)propan-1-amine hydrochloride;847448-32-2;1565825-89-9;(R)-1-(3,4-DIFLUOROPHENYL)PROPAN-1-AMINE HCL;(1R)-1-(3,4-difluorophenyl)propan-1-amine;hydrochloride;(1R)-1-(3,4-DIFLUOROPHENYL)PROPAN-1-AMINE HYDROCHLORIDE;BNFNPNSBDYSQAL-SBSPUUFOSA-N;XIB44832;MFCD12757715;AKOS015923223;AS-69540;CS-0153919;Y10298;(R)-1-(3,4-Difluorophenyl)propan-1-aminehydrochloride;(R)-1-(3,4-Difluorophenyl)propan-1-amine hydrochloride ee

Suppliers and Price of (R)-1-(3,4-Difluorophenyl)propan-1-amine hydrochloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
(R)-1-(3,4-Difluorophenyl)propan-1-amine
50mg
$ 200.00

TRC
(R)-1-(3,4-Difluorophenyl)propan-1-amine
10mg
$ 45.00

TRC
(R)-1-(3,4-Difluorophenyl)propan-1-amine
100mg
$ 310.00

Matrix Scientific
(1S)-1-(3,4-Difluorophenyl)propan-1-amine hydrochloride >97%
1g
$ 648.00

Matrix Scientific
(1S)-1-(3,4-Difluorophenyl)propan-1-amine hydrochloride >97%
500mg
$ 522.00

Crysdot
(R)-1-(3,4-Difluorophenyl)propan-1-aminehydrochloride 95+%
5g
$ 2222.00

Crysdot
(R)-1-(3,4-Difluorophenyl)propan-1-aminehydrochloride 95+%
1g
$ 673.00

Crysdot
(R)-1-(3,4-Difluorophenyl)propan-1-aminehydrochloride 95+%
250mg
$ 269.00

American Custom Chemicals Corporation
(R)-1-(3,4-DIFLUOROPHENYL)PROPAN-1-AMINE HYDROCHLORIDE 95.00%
5MG
$ 495.47

Alichem
(R)-1-(3,4-Difluorophenyl)propan-1-aminehydrochloride
250mg
$ 299.20

Total 13 raw suppliers

Chemical Property of (R)-1-(3,4-Difluorophenyl)propan-1-amine hydrochloride

Chemical Property:

PSA：26.02000
LogP:3.87690
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:207.0626334
Heavy Atom Count:13
Complexity:141

Purity/Quality:

99%, ^*data from raw suppliers

(R)-1-(3,4-Difluorophenyl)propan-1-amine ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCC(C1=CC(=C(C=C1)F)F)N.Cl
Isomeric SMILES:CC[C@H](C1=CC(=C(C=C1)F)F)N.Cl

Technology Process of (R)-1-(3,4-Difluorophenyl)propan-1-amine hydrochloride

There total 4 articles about (R)-1-(3,4-Difluorophenyl)propan-1-amine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 847448-31-1
4-((R)-1-Azido-propyl)-1,2-difluoro-benzene

: 847448-32-2
(R)-1-(3,4-difluorophenyl)propylamine

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol;
DOI:10.1016/j.bmcl.2004.11.064

Reference yield:

: 34036-07-2
3,4 difluorobenzaldehyde

: 847448-32-2
(R)-1-(3,4-difluorophenyl)propylamine

Guidance literature:: Multi-step reaction with 3 steps

1: 100 percent / Ti(i-PropO)4; 1R,2R-1,2-di(CF₃SO₂NH)-cyclohexane / toluene / -78 °C

2: 75 percent / diphenylphosphorylazide; DBU / toluene

3: 75 percent / H₂ / Pd/C / methanol

With titanium(IV) isopropylate; diphenylphosphoranyl azide; hydrogen; N,N’-(1R,2R)-cyclohexane-1,2-diylbis(1,1,1-trifluoromethanesulfonamide); 1,8-diazabicyclo[5.4.0]undec-7-ene; palladium on activated charcoal; In methanol; toluene;
DOI:10.1016/j.bmcl.2004.11.064

Reference yield:

: 847448-30-0
(S)-1-(3,4-Difluoro-phenyl)-propan-1-ol

: 847448-32-2
(R)-1-(3,4-difluorophenyl)propylamine

Guidance literature:: Multi-step reaction with 2 steps

1: 75 percent / diphenylphosphorylazide; DBU / toluene

2: 75 percent / H₂ / Pd/C / methanol

With diphenylphosphoranyl azide; hydrogen; 1,8-diazabicyclo[5.4.0]undec-7-ene; palladium on activated charcoal; In methanol; toluene;
DOI:10.1016/j.bmcl.2004.11.064