3-bromophenylglycine

Base Information

• Chemical Name: 3-bromophenylglycine
• CAS No.: 42288-20-0
• Molecular Formula: C8H8BrNO2
• Molecular Weight: 230.05862
• Hs Code.: 2922499990
• Mol file: 42288-20-0.mol

Synonyms:3-bromophenylglycine

Chemical Property of 3-bromophenylglycine

Chemical Property:

• Boiling Point: 413.7±30.0 °C(Predicted)
• PKA: 4.09±0.20(Predicted)
• PSA: 148.97000
• Density: 1.689±0.06 g/cm3(Predicted)
• LogP: 4.24740

Purity/Quality:

99%min ^*data from raw suppliers

N-(3-Bromophenyl)glycine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-bromophenylglycine

There total 4 articles about 3-bromophenylglycine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

ethyl bromoacetate (105-36-2) + m-Bromoaniline (591-19-5) → 2-((3-bromophenyl)amino)acetic acid (42288-20-0)

Guidance literature:

ethyl bromoacetate; m-Bromoaniline; With potassium carbonate; for 1.5h; Milling;

With potassium hydroxide; for 1.5h; Milling;

DOI:10.1039/c9cc04673a

Reference yield:

m-bromobenzoic aldehyde (3132-99-8) → 2-((3-bromophenyl)amino)acetic acid (42288-20-0)

Guidance literature:

With hydrogenchloride; potassium hydroxide; N-benzyl-N,N,N-triethylammonium chloride; lithium chloride; In ammonium hydroxide; dichloromethane; chloroform; water;

Reference yield:

m-Bromoaniline (591-19-5) → 2-((3-bromophenyl)amino)acetic acid (42288-20-0)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium acetate; ethanol

With ethanol; sodium acetate;

DOI:10.1039/jr9480002307

upstream raw materials:

ethyl N-(3-bromophenyl)glycinate

m-Bromoaniline

m-bromobenzoic aldehyde

ethyl bromoacetate

Downstream raw materials:

ethyl N-(3-bromophenyl)glycinate

3-(3-bromophenyl)sydnone

Refernces

• 1、 -. "Pharmaceutical compositions containing a 4, 5-dihydro-1, 3-thiazol-2-ylamine derivative, novel derivatives and preparation thereof". . . Retrieved 2011/05/18.