2-Amino-5-(trifluoromethyl)benzyl alcohol

Base Information

• Chemical Name: 2-Amino-5-(trifluoromethyl)benzyl alcohol
• CAS No.: 220107-65-3
• Molecular Formula: C8H8F3NO
• Molecular Weight: 191.153
• Mol file: 220107-65-3.mol

Synonyms:2-Amino-5-(trifluoromethyl)benzyl alcohol;2-Amino-5-(trifluoromethyl)benzenemethanol;

Chemical Property of 2-Amino-5-(trifluoromethyl)benzyl alcohol

Chemical Property:

• Boiling Point: 270℃
• Flash Point: 117℃
• PSA: 46.25000
• Density: 1.374
• LogP: 2.36110
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

97% ^*data from raw suppliers

(2-Amino-5-(trifluoromethyl)phenyl)methanol 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Amino-5-(trifluoromethyl)benzyl alcohol

There total 2 articles about 2-Amino-5-(trifluoromethyl)benzyl alcohol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

2-amino-5-(trifluoromethyl)benzoic acid (83265-53-6) → 2-Amino-5-(trifluoromethyl)benzyl alcohol (220107-65-3)

Guidance literature:

With borane-THF; In tetrahydrofuran; at 0 - 30 ℃; for 23h; Inert atmosphere;

DOI:10.1016/j.bmc.2012.08.004

Reference yield:

methyl 2-Amino-5-trifluoromethylbenzoate (117324-58-0) → 2-Amino-5-(trifluoromethyl)benzyl alcohol (220107-65-3)

Guidance literature:

methyl 2-Amino-5-trifluoromethylbenzoate; With lithium aluminium tetrahydride; In tetrahydrofuran; for 2h; Cooling;

With sodium hydroxide; water; In tetrahydrofuran;

Reference yield: 78.0%

2-Amino-5-(trifluoromethyl)benzyl alcohol (220107-65-3) → 2-amino-5-(trifluoromethyl)benzaldehyde (1288999-05-2)

Guidance literature:

With boron tribromide; In dichloromethane; at 0 - 20 ℃; for 1h; Inert atmosphere;

DOI:10.1016/j.bmc.2012.08.004

upstream raw materials:

2-amino-5-(trifluoromethyl)benzoic acid

methyl 2-Amino-5-trifluoromethylbenzoate

Downstream raw materials:

[2-iodo-5-(trifluoromethyl)phenyl]methanol

2-amino-5-(trifluoromethyl)benzaldehyde