3-Chloro-4-trifluoromethoxy acetophenone

Base Information

• Chemical Name: 3-Chloro-4-trifluoromethoxy acetophenone
• CAS No.: 129604-27-9
• Molecular Formula: C9H6ClF3O2
• Molecular Weight: 238.594
• Mol file: 129604-27-9.mol

Synonyms:1-[3-Chloro-4-(trifluoromethoxy)phenyl]ethanone;

Chemical Property of 3-Chloro-4-trifluoromethoxy acetophenone

Chemical Property:

• Vapor Pressure: 0.0119mmHg at 25°C
• Melting Point: 98-99
• Refractive Index: 1.48
• Boiling Point: 261℃
• Flash Point: 107℃
• PSA: 26.30000
• Density: 1.376
• LogP: 3.44120
• Storage Temp.: Sealed in dry,Room Temperature
• Water Solubility.: Slightly soluble in water.

Purity/Quality:

99% ^*data from raw suppliers

1-(3-Chloro-4-(Trifluoromethoxy)Phenyl)Ethanone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 3'-Chloro-4'-(trifluoromethoxy)acetophenone is used as an organic chemical synthesis intermediate.

Technology Process of 3-Chloro-4-trifluoromethoxy acetophenone

There total 1 articles about 3-Chloro-4-trifluoromethoxy acetophenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

methyl magnesium iodide (917-64-6) + 3-chloro-4-(trifluoromethoxy)benzonitrile (129604-26-8) → 3-Chloro-4-trifluoromethoxy-acetophenone (129604-27-9)

Guidance literature:

Reference yield:

3-Chloro-4-trifluoromethoxy-acetophenone (129604-27-9) → C9H5BrClF3O2

Guidance literature:

With bromine; In diethyl ether; at 20 ℃; for 2h;

Reference yield:

3-Chloro-4-trifluoromethoxy-acetophenone (129604-27-9) → C10H5ClF3NO2S

Guidance literature:

Multi-step reaction with 2 steps

1: bromine / diethyl ether / 2 h / 20 °C

2: ethanol / 1 h / 20 °C

With bromine; In diethyl ether; ethanol;

upstream raw materials:

methyl magnesium iodide

3-chloro-4-(trifluoromethoxy)benzonitrile

Refernces

• 1、 -. "Fluorine-containing acetophenones optionally halogenated on the CH3 -group and their precurser fluorine-containing benzonitriles". . . Retrieved 2008/06/13.