(R)-1-Boc-4-benzyl-2-(hydroxymethyl)piperazine

Base Information

• Chemical Name: (R)-1-Boc-4-benzyl-2-(hydroxymethyl)piperazine
• CAS No.: 1257855-72-3
• Molecular Formula: C17H26N2O3
• Molecular Weight: 306.4
• Hs Code.: 2933599090

Synonyms:BH117;FC0162;(R)-1-Boc-4-benzyl-2-(hydroxymethyl)piperazine;(R)-tert-Butyl 4-benzyl-2-(hydroxymethyl)piperazine-1-carboxylate;

Chemical Property of (R)-1-Boc-4-benzyl-2-(hydroxymethyl)piperazine

Chemical Property:

• PSA: 53.01000
• LogP: 1.97600

Purity/Quality:

97% ^*data from raw suppliers

(R)-1-Boc-4-benzyl-2-(hydroxymethyl)piperazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (R)-1-Boc-4-benzyl-2-(hydroxymethyl)piperazine

There total 15 articles about (R)-1-Boc-4-benzyl-2-(hydroxymethyl)piperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

di-tert-butyl dicarbonate (24424-99-5) + 4-(phenylmethyl)-2-piperazinemethanol (85817-34-1) → tert-butyl 4-benzyl-2-(hydroxymethyl)piperazine-1-carboxylate (936553-15-0,1257855-72-3,947275-34-5)

Guidance literature:

In dichloromethane; at 20 ℃; for 4h;

DOI:10.1016/j.bmc.2007.03.001

Reference yield: 83.0%

(S)-2-(hydroxymethyl)piperazine-1-carboxylic acid tert-butyl ester (1030377-21-9) + benzaldehyde (100-52-7) → (S)-tert-butyl 4-benzyl-2-(hydroxymethyl)piperazine-1-carboxylate (1257855-72-3,947275-34-5)

Guidance literature:

(S)-2-(hydroxymethyl)piperazine-1-carboxylic acid tert-butyl ester; benzaldehyde; In 1,2-dichloro-ethane; at 20 ℃; for 0.5h;

With sodium tris(acetoxy)borohydride; In 1,2-dichloro-ethane; at 20 ℃;

Reference yield: 64.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + 4-benzyl-piperazine-1-carboxylic acid tert-butyl ester (57260-70-5) → tert-butyl 4-benzyl-2-(hydroxymethyl)piperazine-1-carboxylate (936553-15-0,1257855-72-3,947275-34-5)

Guidance literature:

4-benzyl-piperazine-1-carboxylic acid tert-butyl ester; With sec.-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 1h; Inert atmosphere;

formaldehyd; In tetrahydrofuran; hexane; at -78 - 20 ℃; for 0.75h; Inert atmosphere;

DOI:10.1021/acs.joc.7b00913

upstream raw materials:

di-tert-butyl dicarbonate

4-(phenylmethyl)-2-piperazinemethanol

4-benzyl-piperazine-1,2-dicarboxylic acid 1-tert-butyl ester

benzyl bromide

Downstream raw materials:

4-(phenylmethyl)-2-piperazinemethanol

N¹-(((R)-4-benzylpiperazin-2-yl)methyl)-N¹-((S)-5,6,7,8-tetrahydroquinolin-8-yl)butane-1,4-diamine

N¹-(((S)-4-benzylpiperazin-2-yl)methyl)-N¹-((S)-5,6,7,8-tetrahydroquinolin-8-yl)butane-1,4-diamine

(S)-2-(hydroxymethyl)piperazine-1-carboxylic acid tert-butyl ester

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