2,4-Difluoro-5-methoxynitrobenzene

Base Information

• Chemical Name: 2,4-Difluoro-5-methoxynitrobenzene
• CAS No.: 179011-39-3
• Molecular Formula: C7H5F2NO3
• Molecular Weight: 189.118
• Hs Code.: 2909309090
• Mol file: 179011-39-3.mol

Synonyms:2,4-Difluoro-5-nitrophenyl methyl ether; benzene, 1,5-difluoro-2-methoxy-4-nitro-

Chemical Property of 2,4-Difluoro-5-methoxynitrobenzene

Chemical Property:

• Vapor Pressure: 0.00542mmHg at 25°C
• Boiling Point: 283.4°C at 760 mmHg
• Flash Point: 125.2°C
• PSA: 55.05000
• Density: 1.414g/cm³
• LogP: 2.40480
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

1,5-Difluoro-2-methoxy-4-nitrobenzene ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,4-Difluoro-5-methoxynitrobenzene

There total 1 articles about 2,4-Difluoro-5-methoxynitrobenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,4-difluoro-5-nitrophenol (113512-57-5) + methyl iodide (74-88-4) → 1,5-difluoro-2-methoxy-4-nitrobenzene (179011-39-3)

Guidance literature:

2,4-difluoro-5-nitrophenol; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 0 ℃; for 0.5h; Inert atmosphere;

methyl iodide; In N,N-dimethyl-formamide; mineral oil; at 20 ℃; for 12h; Inert atmosphere;

Reference yield: 95.0%

1,5-difluoro-2-methoxy-4-nitrobenzene (179011-39-3) → 2,4-difluoro-5-methoxyaniline (98446-51-6)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In ethanol; at 20 ℃; for 72h; Inert atmosphere;

Reference yield: 18.0%

3-methyl-1H-[1,2,4]triazole (7170-01-6) + 1,5-difluoro-2-methoxy-4-nitrobenzene (179011-39-3) → 1-(5-fluoro-2-methoxy-4-nitrophenyl)-3-methyl-1H-1,2,4-triazole (1235491-97-0)

Guidance literature:

With potassium carbonate; In dimethyl sulfoxide; at 80 ℃; for 24h;

upstream raw materials:

2,4-difluoro-5-nitrophenol

methyl iodide

Downstream raw materials:

1-(5-fluoro-2-methoxy-4-nitrophenyl)-3-methyl-1H-1,2,4-triazole

2-fluoro-5-methoxy-4-(3-methyl-1H-1,2,4-triazol-1-yl)aniline

2,4-difluoro-5-methoxyaniline

1-bromo-2,4-difluoro-5-methoxybenzene

Refernces