3-Amino-1-Boc-3-methylpiperidine

Base Information

• Chemical Name: 3-Amino-1-Boc-3-methylpiperidine
• CAS No.: 1158759-06-8
• Molecular Formula: C11H22N2O2
• Molecular Weight: 214.30458
• Hs Code.: 2933399090
• Mol file: 1158759-06-8.mol

Synonyms:tert-butyl 3-amino-3-methylpiperidine-1-carboxylate; tert-Butyl 3-amino-3-methylpiperidine-1-carboxylate

Chemical Property of 3-Amino-1-Boc-3-methylpiperidine

Chemical Property:

• Boiling Point: 283.0±33.0 °C(Predicted)
• PKA: 9.55±0.20(Predicted)
• PSA: 55.56000
• Density: 1.017±0.06 g/cm3(Predicted)
• LogP: 2.37290
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

99%, ^*data from raw suppliers

tert-Butyl3-Amino-3-methylpiperidine-1-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Amino-1-Boc-3-methylpiperidine

There total 4 articles about 3-Amino-1-Boc-3-methylpiperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

tert-butyl 3-isocyanato-3-methylpiperidine-1-carboxylate (534602-48-7) → tert-butyl 3-amino-3-methylpiperidine-1-carboxylate (1158759-06-8,1962928-76-2)

Guidance literature:

With sodium hydroxide; In tetrahydrofuran; water; at 20 ℃;

Reference yield:

1-(tert-butyl) 3-methyl piperidine-1,3-dicarboxylate (148763-41-1) → tert-butyl 3-amino-3-methylpiperidine-1-carboxylate (1158759-06-8,1962928-76-2)

Guidance literature:

Multi-step reaction with 4 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -65 °C / Inert atmosphere

1.2: 3 h / -65 - 20 °C

2.1: lithium hydroxide monohydrate / tetrahydrofuran; water / 6 h / 70 °C

3.1: triethylamine; diphenyl phosphoryl azide / toluene / 2.5 h / 20 - 90 °C

4.1: sodium hydroxide / tetrahydrofuran; water / 20 °C

With lithium hydroxide monohydrate; diphenyl phosphoryl azide; triethylamine; sodium hydroxide; lithium hexamethyldisilazane; In tetrahydrofuran; water; toluene;

Reference yield:

1-(tert-butyl) 3-methyl 3-methylpiperidine-1,3-dicarboxylate (888952-55-4) → tert-butyl 3-amino-3-methylpiperidine-1-carboxylate (1158759-06-8,1962928-76-2)

Guidance literature:

Multi-step reaction with 3 steps

1: lithium hydroxide monohydrate / tetrahydrofuran; water / 6 h / 70 °C

2: triethylamine; diphenyl phosphoryl azide / toluene / 2.5 h / 20 - 90 °C

3: sodium hydroxide / tetrahydrofuran; water / 20 °C

With lithium hydroxide monohydrate; diphenyl phosphoryl azide; triethylamine; sodium hydroxide; In tetrahydrofuran; water; toluene;

upstream raw materials:

tert-butyl 3-isocyanato-3-methylpiperidine-1-carboxylate

1-(tert-butyl) 3-methyl piperidine-1,3-dicarboxylate

1-(tert-butyl) 3-methyl 3-methylpiperidine-1,3-dicarboxylate

1-(tert-butoxycarbonyl)-3-methylpiperidine-3-carboxylic acid

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