1-(Tert-butoxycarbonyl)-3-methylpiperidine-3-carboxylic acid

Base Information

Chemical Name:1-(Tert-butoxycarbonyl)-3-methylpiperidine-3-carboxylic acid
CAS No.:534602-47-6
Molecular Formula:C12H21NO4
Molecular Weight:243.303
Hs Code.:2933399090
European Community (EC) Number:963-329-7
DSSTox Substance ID:DTXSID00595188
Mol file:534602-47-6.mol

Synonyms:534602-47-6;1-(tert-butoxycarbonyl)-3-methylpiperidine-3-carboxylic acid;1-BOC-3-METHYLPIPERIDINE-3-CARBOXYLIC ACID;1-n-boc-3-methylpiperidine-3-carboxylic acid;1-[(TERT-BUTOXY)CARBONYL]-3-METHYLPIPERIDINE-3-CARBOXYLIC ACID;3-methyl-1-[(2-methylpropan-2-yl)oxycarbonyl]piperidine-3-carboxylic acid;MFCD08461329;1,3-piperidinedicarboxylic acid, 3-methyl-, 1-(1,1-dimethylethyl) ester;MFCD28501395;1-N-Boc-3-methyl-piperidine-3-carboxylic acid;SCHEMBL2279068;DTXSID00595188;LNQIKLOOSITZGB-UHFFFAOYSA-N;3-Methyl-1,3-piperidinedicarboxylic acid 1-(1,1-dimethylethyl) ester;STL185835;AKOS004910716;AC-6313;BS-4531;CCG-211591;CS-W003532;PB11848;SY018679;SY245241;DB-011981;N-Boc-3-methylpiperidine-3-carboxylic Acid;N-Boc-3-methyl-piperidine-3-carboxylic acid;EN300-68602;A26690;(S)-1-Boc-3-methylpiperidine-3-carboxylic Acid;J-504358;Z1095260368;1-(tert-butoxycarbonyl)-3-methylpiperidine-3-carboxylicacid;1-(TERT-BUTOXYCARBONYL)-3-METHYL-3-PIPERIDINECARBOXYLIC ACID;rac-3-methyl-piperidine-1,3-dicarboxylic acid 1-tert-butyl ester;3-METHYL-PIPERIDINE-1,3-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER;1-(tert-Butoxycarbonyl)-3-methylpiperidine-3-carboxylic acid;1-Boc-3-methylpiperidine-3-carboxylic Acid

Suppliers and Price of 1-(Tert-butoxycarbonyl)-3-methylpiperidine-3-carboxylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
N-Boc-3-methylpiperidine-3-carboxylicAcid
5g
$ 580.00

Synthonix
1-Boc-3-methylpiperidine-3-carboxylicacid 97.0%
1g
$ 40.00

SynQuest Laboratories
1-[(tert-Butoxy)carbonyl]-3-methylpiperidine-3-carboxylic acid 97.0%
25 g
$ 1590.00

SynQuest Laboratories
1-[(tert-Butoxy)carbonyl]-3-methylpiperidine-3-carboxylic acid 97.0%
5 g
$ 940.00

SynQuest Laboratories
1-[(tert-Butoxy)carbonyl]-3-methylpiperidine-3-carboxylic acid 97.0%
250 mg
$ 115.00

SynQuest Laboratories
1-[(tert-Butoxy)carbonyl]-3-methylpiperidine-3-carboxylic acid 97.0%
1 g
$ 290.00

Matrix Scientific
3-Methyl-piperidine-1,3-dicarboxylic acid 1-tert-butyl ester
1g
$ 175.00

Crysdot
1-(tert-Butoxycarbonyl)-3-methylpiperidine-3-carboxylicacid 97%
1g
$ 61.00

Chemenu
1-[(tert-butoxy)carbonyl]-3-methylpiperidine-3-carboxylicacid 97%
100g
$ 847.00

Chemenu
1-[(tert-butoxy)carbonyl]-3-methylpiperidine-3-carboxylicacid 97%
25g
$ 297.00

Total 35 raw suppliers

Chemical Property of 1-(Tert-butoxycarbonyl)-3-methylpiperidine-3-carboxylic acid

Chemical Property:

Vapor Pressure:5.65E-06mmHg at 25°C
Refractive Index:1.489
Boiling Point:359.512 °C at 760 mmHg
PKA:4.53±0.20(Predicted)
Flash Point:171.227 °C
PSA：66.84000
Density:1.122 g/cm³
LogP:2.04610
Storage Temp.:Sealed in dry,Room Temperature
XLogP3:1.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:3
Exact Mass:243.14705815
Heavy Atom Count:17
Complexity:321

Purity/Quality:

97% ^*data from raw suppliers

N-Boc-3-methylpiperidine-3-carboxylicAcid ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1(CCCN(C1)C(=O)OC(C)(C)C)C(=O)O
Uses N-Boc-3-methylpiperidine-3-carboxylic Acid is used as a reagent in the synthesis of tricyclic heterocyclic compounds as JAK1 inhibitors useful in the treatment of immunological and hyperproliferative disorders.

Technology Process of 1-(Tert-butoxycarbonyl)-3-methylpiperidine-3-carboxylic acid

There total 3 articles about 1-(Tert-butoxycarbonyl)-3-methylpiperidine-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 888952-55-4
1-(tert-butyl) 3-methyl 3-methylpiperidine-1,3-dicarboxylate

: 534602-47-6,1415018-75-5,1415018-76-6
1-(tert-butoxycarbonyl)-3-methylpiperidine-3-carboxylic acid

Guidance literature:: With lithium hydroxide monohydrate; In tetrahydrofuran; water; at 70 ℃; for 6h;

Reference yield: 90.0%

: 534602-47-6,1415018-75-5,1415018-76-6
1-(tert-butoxycarbonyl)-3-methylpiperidine-3-carboxylic acid

Guidance literature:

Reference yield:

: 148763-41-1
1-(tert-butyl) 3-methyl piperidine-1,3-dicarboxylate

: 534602-47-6,1415018-75-5,1415018-76-6
1-(tert-butoxycarbonyl)-3-methylpiperidine-3-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -65 °C / Inert atmosphere

1.2: 3 h / -65 - 20 °C

2.1: lithium hydroxide monohydrate / tetrahydrofuran; water / 6 h / 70 °C

With lithium hydroxide monohydrate; lithium hexamethyldisilazane; In tetrahydrofuran; water;