2-Phenoxypyridin-5-yl boronic acid hydrochloride

Base Information

• Chemical Name: 2-Phenoxypyridin-5-yl boronic acid hydrochloride
• CAS No.: 1270921-80-6
• Molecular Formula: C11H11BClNO3
• Molecular Weight: 215.016
• Hs Code.: 2933399990
• Mol file: 1270921-80-6.mol

Synonyms:6-Phenoxypyridine-3-boronic acid;

Chemical Property of 2-Phenoxypyridin-5-yl boronic acid hydrochloride

Chemical Property:

• Boiling Point: 404.0±55.0 °C(Predicted)
• PKA: 7.06±0.10(Predicted)
• PSA: 62.58000
• Density: 1.29±0.1 g/cm3(Predicted)
• LogP: 0.55370
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

(6-Phenoxypyridin-3-yl)boronicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Phenoxypyridin-5-yl boronic acid hydrochloride

There total 7 articles about 2-Phenoxypyridin-5-yl boronic acid hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

Triisopropyl borate (5419-55-6) + 5-bromo-2-phenoxypyridine (59717-96-3) → (6-phenoxypyridin-3-yl)boronic acid (1270921-80-6)

Guidance literature:

Triisopropyl borate; 5-bromo-2-phenoxypyridine; With iodine; magnesium; isobutyryl chloride; In tetrahydrofuran; at 0 - 50 ℃; Inert atmosphere; Large scale;

With hydrogenchloride; In tetrahydrofuran; water; at -5 ℃; pH=6; Inert atmosphere; Large scale;

Reference yield:

C17H22BNO3 → (6-phenoxypyridin-3-yl)boronic acid (1270921-80-6)

Guidance literature:

C₁₇H₂₂BNO₃; With sodium hydroxide; In water; at 20 ℃;

With hydrogenchloride; In water;

DOI:10.1016/j.ejmech.2015.02.056

Reference yield:

2,5-dibromopyridine (624-28-2) → (6-phenoxypyridin-3-yl)boronic acid (1270921-80-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium carbonate / N,N-dimethyl-formamide / 24 h / 105 °C / Large scale

2.1: magnesium; iodine; isobutyryl chloride / tetrahydrofuran / 0 - 50 °C / Inert atmosphere; Large scale

2.2: -5 °C / pH 6 / Inert atmosphere; Large scale

With iodine; sodium carbonate; magnesium; isobutyryl chloride; In tetrahydrofuran; N,N-dimethyl-formamide;

upstream raw materials:

2,5-dibromopyridine

phenol

Triisopropyl borate

5-bromo-2-phenoxypyridine

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