2-Chloro-3-fluoro-benzylamine

Base Information

• Chemical Name: 2-Chloro-3-fluoro-benzylamine
• CAS No.: 72235-54-2
• Molecular Formula: C7H7ClFN
• Molecular Weight: 159.591
• Hs Code.: 2921490090
• Mol file: 72235-54-2.mol

Synonyms:2-CHLORO-3-FLUORO-BENZYLAMINE

Chemical Property of 2-Chloro-3-fluoro-benzylamine

Chemical Property:

• Vapor Pressure: 0.14mmHg at 25°C
• Boiling Point: 216.5°C at 760 mmHg
• Flash Point: 84.7°C
• PSA: 26.02000
• Density: 1.27g/cm³
• LogP: 2.63810
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

98%,99%, ^*data from raw suppliers

(2-Chloro-3-fluorophenyl)methanamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Chloro-3-fluoro-benzylamine

There total 1 articles about 2-Chloro-3-fluoro-benzylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-chloro-3-fluoro-benzaldehyde (96516-31-3) → (2-chloro-3-fluorophenyl)methanamine (72235-54-2)

Guidance literature:

2-chloro-3-fluoro-benzaldehyde; With lithium hexamethyldisilazane; In tetrahydrofuran; at 0 ℃; for 3h;

With lithium aluminium tetrahydride; In tetrahydrofuran; for 3h;

With water; ammonium chloride; rochelle salt; In tetrahydrofuran; Ice cooling;

Reference yield: 91.0%

methyl 3-fluoro-4-nitrobenzoate (185629-31-6) + (2-chloro-3-fluorophenyl)methanamine (72235-54-2) → methyl 3-((2-chloro-3-fluorobenzyl)amino)-4-nitrobenzoate

Guidance literature:

With triethylamine; In water; N,N-dimethyl-formamide; at 50 ℃; for 5h;

DOI:10.1021/acs.jmedchem.1c01196

Reference yield: 90.0%

(2-chloro-3-fluorophenyl)methanamine (72235-54-2) + 4-Benzyl-2-thioxo-3,4-dihydro-1H-pyrido[3,2-e][1,4]diazepin-5(2H)-one (1437787-09-1) → 4-benzyl-2-(2-chloro-3-fluorobenzylamino)-3H-pyrido[3,2-e][1,4]diazepin-5(4H)-one (1437787-20-6)

Guidance literature:

With mercury dichloride; In tetrahydrofuran; at 100 ℃; for 1h; Inert atmosphere;

DOI:10.1016/j.tet.2013.04.089

upstream raw materials:

2-chloro-3-fluoro-benzaldehyde

Downstream raw materials:

N-(2-chloro-3-fluoro-benzyl)-4,5-dihydro-1H-imidazol-2-amine

4-benzyl-2-(2-chloro-3-fluorobenzylamino)-3H-pyrido[3,2-e][1,4]diazepin-5(4H)-one

Refernces