96516-31-3

Upstream product

• 96516-32-4 (2-chloro-3-fluorophenyl)methanol 
• 102940-86-3 3-chloro-3-fluorobenzoic acid 
• 116850-28-3 2-chloro-1-fluoro-3-methylbenzene 

Downstream Products

• 72235-54-2 (2-chloro-3-fluorophenyl)methanamine 
• 1292850-10-2 N-{4-chloro-2-[(2-chloro-3-fluorophenyl)hydroxymethyl]-phenyl}-2,2-dimethylpropionamide 
• 1292850-11-3 [5-chloro-2-(2,2-dimethylpropylamino)phenyl]-(2-chloro-3-fluorophenyl)methanol 
• 1397714-32-7 (S)-3-(2-chloro-3-fluorophenyl)-3-((R)-2-methylpropane-2-sulfinylamino)propionic acid methyl ester 
• 1397714-31-6 N-[1-(2-chloro-3-fluorophenyl)meth-(E)-ylidene]-2-methylpropane-2-sulfinamide 

Relevant academic research and scientific papers

Discovery of a new 2-aminobenzhydrol template for highly potent squalene synthase inhibitors

To obtain small and efficient squalene synthase inhibitors, a flexible 2-aminobenzhydrol open form structure was designed and showed potent inhibitory activity comparable to 4,1-benzoxazepin compounds. Further chemical modification led to the discovery of a novel template with a strong squalene synthase inhibitory activity, and its basic structure-activity relationship was revealed. The X-ray crystallographic data of compound 12 bound to the active site of squalene synthase provided an important insight into the binding mode of this alternative template that formed 11-membered ring conformations with an intramolecular hydrogen bond.

Synthesis and antihypertensive activity of 1,4-dihydropyridine derivatives with a 4-(disubstituted phenyl) ring and an aminoalkyl ester group: Highly potent and long-lasting calcium antagonists

New 1,4-dihydropyridine derivatives bearing a 4-(disubstituted phenyl) ring and an aminoethyl ester or an amino-2,2-dimethylpropyl ester were synthesized and their antihypertensive activities were examined in normotensive rats and spontaneously hypertensi

2-(2-quinazolinylaminoalkoxymethyl)-1,4-dihydropyridine derivatives as cardiovascular agents

Dihydropyridines of the formulae STR1 wherein R is chlorothienyl or mono- or disubstituted phenyl where said substituent is fluoro, chloro, bromo or trifluoromethyl; R1 and R2 are each alykl; R3 and R4 when taken separately are each hydrogen or alkyl; R3 and R4 when taken together with the nitrogen to which they are attached are piperidine or pyrrolidine; R5 is alkyl or 2-hydroxyethyl; R6 is hydrogen or methoxy; X and Z are each hydrogen or methoxy; Y is alkylene; R7 is chlorophenyl or trifluoromethyl-chlorophenyl; p is 0 or 1; and Q is CH or N are useful in the treatment of hypertension, heart failure and angina.