L-PHENYLALANINE-3,3-D2

Base Information

• Chemical Name: L-PHENYLALANINE-3,3-D2
• CAS No.: 221346-31-2
• Molecular Formula: C6H5CH2CD(NH2)COOH
• Molecular Weight: 167.176
• Mol file: 221346-31-2.mol

Synonyms:L-PHENYLALANINE-D2;

Chemical Property of L-PHENYLALANINE-3,3-D2

Chemical Property:

• Melting Point: 270-275?°C (dec.)(lit.)
• PSA: 63.32000
• LogP: 1.34130

Purity/Quality:

97% ^*data from raw suppliers

L-Phenylalanine-3,3-d2 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: L-Phenylalanine-3,3-d2 (CAS# 221346-31-2) is a useful isotopically labeled research compound.

Technology Process of L-PHENYLALANINE-3,3-D2

There total 2 articles about L-PHENYLALANINE-3,3-D2 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

L-phenylalanine (63-91-2,25191-15-5,658-69-5,67675-33-6) → [3,3-(2)H2]-(2S)-α-phenylalanine (221346-31-2)

Guidance literature:

With 5%-palladium/activated carbon; water-d2; aluminium; at 120 ℃; for 0.5h; Time; regioselective reaction; Catalytic behavior; Microwave irradiation;

DOI:10.3390/molecules27030614

Reference yield:

L-phenylalanine (63-91-2,25191-15-5,658-69-5,67675-33-6) → C9H15(2)H2NO2 + [3,3-(2)H2]-(2S)-α-phenylalanine (221346-31-2)

Guidance literature:

With hydrogen; water-d2; palladium on activated charcoal; at 110 ℃; for 6h; Further Variations:; reaction time; Product distribution;

DOI:10.1055/s-2005-863730

Reference yield: 78.0%

methanol (67-56-1) + [3,3-(2)H2]-(2S)-α-phenylalanine (221346-31-2) → methyl L-phenylalaninate-d2 hydrochloride (1264367-65-8)

Guidance literature:

With thionyl chloride; at 0 ℃; for 6h; Reflux;

upstream raw materials:

L-phenylalanine

Downstream raw materials:

C₉H₉⁽²⁾H₂NO₂

methyl L-phenylalaninate-d2 hydrochloride

Refernces

• 1、 Kadish, Dora,Kokel, Anne,T?r?k, Béla. "Preparation of Deuterium Labeled Compounds by Pd/C-Al-D2O Facilitated Selective H-D Exchange Reactions". supporting information. . Retrieved 2022/01/24.