Ethyl--d2 Alcohol-OD

Base Information

• Chemical Name: Ethyl--d2 Alcohol-OD
• CAS No.: 22544-42-9
• Molecular Formula: CH3CD2OD
• Molecular Weight: 49.0452
• Mol file: 22544-42-9.mol

Synonyms:ETHYL--D2 ALCOHOL-OD;α,α,O-Trideuteroethanol;Ethyl-1,1-d2Alcohol-OD;1,1-O-Trideuterio-Aethanol;1,1-Dideutero-1-deuterooxy-ethan;Ethyl-1,1-d2 Alcohol-OD;1,1-Deuterio-1-deuteriooxy-ethan;1,1,O-Trideuteroethanol;1,1,O-trideuterio-ethanol;

Chemical Property of Ethyl--d2 Alcohol-OD

Chemical Property:

• PSA: 20.23000
• LogP: -0.00140

Purity/Quality:

97% ^*data from raw suppliers

Ethyl-1,1-d2Alcohol-OD ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: Ethyl-1,1-d2 Alcohol-OD (CAS# 22544-42-9) is a useful isotopically labeled research compound.

Technology Process of Ethyl--d2 Alcohol-OD

There total 5 articles about Ethyl--d2 Alcohol-OD which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

[D3]acetonitrile (2206-26-0) + [(Ph2PC6H4CH2S)2(C2H4)Ni-COCH3]BPh4 → ethanol-d6 (1516-08-1) + 2,2,2-trideuteroethanol (1759-87-1) + acetaldehyde-2,2,2-d3 (19901-15-6) + ethanol-d3 (22544-42-9) + ((Ph2PC6H4CH2S)2(C2H4))Ni + acetaldehyde (75-07-0,9002-91-9)

Guidance literature:

With tetrabutylammonium borohydride; for 0.0833333h; Inert atmosphere; Schlenk technique; Glovebox;

DOI:10.1021/acs.organomet.7b00472

Reference yield:

acetic acid (64-19-7,77671-22-8) → ethanol-d3 (22544-42-9)

Guidance literature:

With lithium aluminium deuteride; In tetrahydrofuran; at -10 - 20 ℃; for 6h; Inert atmosphere;

Reference yield:

acetic anhydride (108-24-7) → ethanol-d3 (22544-42-9)

Guidance literature:

With lithium aluminium deuteride;

DOI:10.1021/ja00259a012

upstream raw materials:

acetic anhydride

ethanol

[D₃]acetonitrile

acetic acid

Downstream raw materials:

ethyl-1,1-d2 alcohol 4-methylbenzenesulfonate

trans-β-benzoyl-N-p-tolylacrylamide

1,1-dideuterio-1-bromoethane