2-Boc-2,9-DIAZASPIRO[5.5]UNDECAN-1-ONE

Base Information

• Chemical Name: 2-Boc-2,9-DIAZASPIRO[5.5]UNDECAN-1-ONE
• CAS No.: 1198284-94-4
• Molecular Formula: C14H24N2O3
• Molecular Weight: 268.356
• Hs Code.: 2933990090
• Mol file: 1198284-94-4.mol

Synonyms:2-Boc-2,9-DIAZASPIRO[5.5]UNDECAN-1-ONE;9-Boc-1-oxo-2,9-diazaspiro[5.5]undecane

Chemical Property of 2-Boc-2,9-DIAZASPIRO[5.5]UNDECAN-1-ONE

Chemical Property:

• Boiling Point: 438.0±38.0 °C(Predicted)
• PKA: 16.27±0.20(Predicted)
• PSA: 62.13000
• Density: 1.13±0.1 g/cm3(Predicted)
• LogP: 2.12750
• Storage Temp.: 2-8°C

Purity/Quality:

99%, ^*data from raw suppliers

tert-Butyl1-Oxo-2,9-diazaspiro[5.5]undecane-9-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Boc-2,9-DIAZASPIRO[5.5]UNDECAN-1-ONE

There total 6 articles about 2-Boc-2,9-DIAZASPIRO[5.5]UNDECAN-1-ONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

1-tert-butyl 4-ethyl 4-(2-cyanoethyl)piperidine-1,4-dicarboxylate (1313236-57-5) → tert-butyl 1-oxo-2,9-diazaspiro[5.5]undecane-9-carboxylate (1198284-94-4)

Guidance literature:

With ammonia; hydrogen; Raney Ni; In ethanol; at 20 ℃; for 48h; under 5171.62 Torr; autoclave;

Reference yield: 61.0%

1-(tert-butyl) 4-methyl 4-(2-cyanoethyl)piperidine-1,4-dicarboxylate → tert-butyl 1-oxo-2,9-diazaspiro[5.5]undecane-9-carboxylate (1198284-94-4)

Guidance literature:

With ammonia; hydrogen; In methanol; at 50 ℃; under 2585.81 Torr; Autoclave;

Reference yield: 44.0%

4-(3-aminopropyl)-1-[(tert-butoxy)carbonyl]piperidine-4-carboxylic acid → tert-butyl 1-oxo-2,9-diazaspiro[5.5]undecane-9-carboxylate (1198284-94-4)

Guidance literature:

With lithium hydroxide monohydrate; water; In tetrahydrofuran; methanol; at 50 ℃;

upstream raw materials:

1-tert-butyl 4-ethyl 4-(2-cyanoethyl)piperidine-1,4-dicarboxylate

1-tert-butyl 4-ethyl piperidine-1,4-dicarboxylate

di-tert-butyl dicarbonate

1-tert-Butyl 4-methyl piperidine-1,4-dicarboxylate

Downstream raw materials:

tert-butyl 1-oxo-2-((1-tosyl-1H-indol-3-yl)methyl)-2,9-diazaspiro[5.5]undecane-9-carboxylate

2-((1-tosyl-1H-indol-3-yl)methyl)-2,9-diazaspiro[5.5]undecan-1-one trifluoroacetate

9-(quinolin-3-yl)-2-((1-tosyl-1H-indol-3-yl)methyl)-2,9-diazaspiro[5.5]undecan-1-one

2-(2-(2H-1,2,3-triazol-2-yl)benzyl)-9-(quinoxalin-2-yl)-2,9-diazaspiro[5.5]undecan-1-one

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