2-(2-(2H-1,2,3-triazol-2-yl)benzyl)-9-(quinoxalin-2-yl)-2,9-diazaspiro[5.5]undecan-1-one

Base Information

Chemical Name:2-(2-(2H-1,2,3-triazol-2-yl)benzyl)-9-(quinoxalin-2-yl)-2,9-diazaspiro[5.5]undecan-1-one
CAS No.:1313234-50-2
Molecular Formula:C₂₆H₂₇N₇O
Molecular Weight:453.547
Hs Code.:

Synonyms:2-(2-(2H-1,2,3-triazol-2-yl)benzyl)-9-(quinoxalin-2-yl)-2,9-diazaspiro[5.5]undecan-1-one

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Chemical Property of 2-(2-(2H-1,2,3-triazol-2-yl)benzyl)-9-(quinoxalin-2-yl)-2,9-diazaspiro[5.5]undecan-1-one

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Technology Process of 2-(2-(2H-1,2,3-triazol-2-yl)benzyl)-9-(quinoxalin-2-yl)-2,9-diazaspiro[5.5]undecan-1-one

There total 8 articles about 2-(2-(2H-1,2,3-triazol-2-yl)benzyl)-9-(quinoxalin-2-yl)-2,9-diazaspiro[5.5]undecan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 1448-87-9
2-chloroquinoxaline

: 2-(2-(2H-1,2,3-triazol-2-yl)benzyl)-2,9-diazaspiro[5.5]undecan-1-one

: 1313234-50-2
2-(2-(2H-1,2,3-triazol-2-yl)benzyl)-9-(quinoxalin-2-yl)-2,9-diazaspiro[5.5]undecan-1-one

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In acetonitrile; at 120 ℃; for 0.666667h; microwave conditions;

Reference yield:

: 1313236-57-5
1-tert-butyl 4-ethyl 4-(2-cyanoethyl)piperidine-1,4-dicarboxylate

: 1313234-50-2
2-(2-(2H-1,2,3-triazol-2-yl)benzyl)-9-(quinoxalin-2-yl)-2,9-diazaspiro[5.5]undecan-1-one

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogen; ammonia / Raney Ni / ethanol / 48 h / 20 °C / 5171.62 Torr / autoclave

2: sodium hydride; tetra-(n-butyl)ammonium iodide / tetrahydrofuran; mineral oil / 5 h / 0 - 20 °C

3: dichloromethane / 0.42 h / 20 °C

4: N-ethyl-N,N-diisopropylamine / acetonitrile / 0.67 h / 120 °C / microwave conditions

With ammonia; hydrogen; tetra-(n-butyl)ammonium iodide; sodium hydride; N-ethyl-N,N-diisopropylamine; Raney Ni; In tetrahydrofuran; ethanol; dichloromethane; acetonitrile; mineral oil;

Reference yield:

: 142851-03-4
1-tert-butyl 4-ethyl piperidine-1,4-dicarboxylate

: 1313234-50-2
2-(2-(2H-1,2,3-triazol-2-yl)benzyl)-9-(quinoxalin-2-yl)-2,9-diazaspiro[5.5]undecan-1-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: lithium diisopropyl amide / hexane; tetrahydrofuran / 0.5 h / -78 °C

1.2: 4 h / -78 - -60 °C

1.3: -60 °C

2.1: hydrogen; ammonia / Raney Ni / ethanol / 48 h / 20 °C / 5171.62 Torr / autoclave

3.1: sodium hydride; tetra-(n-butyl)ammonium iodide / tetrahydrofuran; mineral oil / 5 h / 0 - 20 °C

4.1: dichloromethane / 0.42 h / 20 °C

5.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 0.67 h / 120 °C / microwave conditions

With ammonia; hydrogen; tetra-(n-butyl)ammonium iodide; sodium hydride; N-ethyl-N,N-diisopropylamine; lithium diisopropyl amide; Raney Ni; In tetrahydrofuran; ethanol; hexane; dichloromethane; acetonitrile; mineral oil;