benzyl (S)-1-((S)-2-((2R,3S)-2-ethoxy-5-oxotetrahydrofuran-3-ylcarbaMoyl)pyrrolidin-1-yl)-3,3-diMethyl-1-oxobutan-2-ylcarbaMate

Base Information

Chemical Name:benzyl (S)-1-((S)-2-((2R,3S)-2-ethoxy-5-oxotetrahydrofuran-3-ylcarbaMoyl)pyrrolidin-1-yl)-3,3-diMethyl-1-oxobutan-2-ylcarbaMate
CAS No.:864167-26-0
Molecular Formula:C25H35N3O7
Molecular Weight:489.569
Hs Code.:
Mol file:864167-26-0.mol

Synonyms:{(S)-1-[(1R,3S,4S)-3-((2R,3S)-2-ethoxy-5-oxotetrahydrofuran-3ylcarbamoyl)-2-pyrrolidine-2-carbonyl]-2,2-dimethylpropyl}carbamic acid benzyl ester;

Suppliers and Price of benzyl (S)-1-((S)-2-((2R,3S)-2-ethoxy-5-oxotetrahydrofuran-3-ylcarbaMoyl)pyrrolidin-1-yl)-3,3-diMethyl-1-oxobutan-2-ylcarbaMate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Matrix Scientific
Benzyl (S)-1-((S)-2-((2R,3S)-2-ethoxy-5-oxotetrahydrofuran-3-ylcarbamoyl)-pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-ylcarbamate 95%
25g
$ 8126.00

Matrix Scientific
Benzyl (S)-1-((S)-2-((2R,3S)-2-ethoxy-5-oxotetrahydrofuran-3-ylcarbamoyl)-pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-ylcarbamate 95%
5g
$ 2709.00

Total 2 raw suppliers

Chemical Property of benzyl (S)-1-((S)-2-((2R,3S)-2-ethoxy-5-oxotetrahydrofuran-3-ylcarbaMoyl)pyrrolidin-1-yl)-3,3-diMethyl-1-oxobutan-2-ylcarbaMate

Chemical Property:

PSA：123.27000
LogP:2.83250

Purity/Quality:

95%-98% ^*data from raw suppliers

Benzyl (S)-1-((S)-2-((2R,3S)-2-ethoxy-5-oxotetrahydrofuran-3-ylcarbamoyl)-pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-ylcarbamate 95% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of benzyl (S)-1-((S)-2-((2R,3S)-2-ethoxy-5-oxotetrahydrofuran-3-ylcarbaMoyl)pyrrolidin-1-yl)-3,3-diMethyl-1-oxobutan-2-ylcarbaMate

There total 4 articles about benzyl (S)-1-((S)-2-((2R,3S)-2-ethoxy-5-oxotetrahydrofuran-3-ylcarbaMoyl)pyrrolidin-1-yl)-3,3-diMethyl-1-oxobutan-2-ylcarbaMate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 864167-16-8
(1S)-2-((2R,3S)-2-ethoxy-5-oxotetrahydrofuran-3-ylcarbamoyl)pyrrolidine-1-carboxylic acid benzyl ester

: 62965-10-0
(S)-N-carbobenzoxy-tert-butylleucine

: 864167-26-0
benzyl (2S)-1-((2S)-2-((2R,3S)-2-ethoxy-5-oxotetrahydrofuran-3-ylcarbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-ylcarbamate

Guidance literature:: (1S)-2-((2R,3S)-2-ethoxy-5-oxotetrahydrofuran-3-ylcarbamoyl)pyrrolidine-1-carboxylic acid benzyl ester; With hydrogen; triethylamine; 20% Pd(OH)2 on carbon; In DMF (N,N-dimethyl-formamide); ethyl acetate;

(S)-N-carbobenzoxy-tert-butylleucine; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In DMF (N,N-dimethyl-formamide); water; ethyl acetate; at 20 ℃;

With sodium hydrogencarbonate; In DMF (N,N-dimethyl-formamide); water; ethyl acetate;

Reference yield: 60.0%

: C₂HF₃O₂*C₁₁H₁₈N₂O₄

: 864167-26-0
benzyl (2S)-1-((2S)-2-((2R,3S)-2-ethoxy-5-oxotetrahydrofuran-3-ylcarbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-ylcarbamate

Guidance literature:: (S)-N-carbobenzoxy-tert-butylleucine; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 22 ℃; for 2h;

C₂HF₃O₂*C₁₁H₁₈N₂O₄; With 4-methyl-morpholine; In dichloromethane; at 22 ℃; for 3h; Product distribution / selectivity;

Reference yield:

: C₁₁H₁₈N₂O₄

: 62965-37-1
(S)-2-(((benzyloxy)carbonyl)amino)-3,3-dimethylbutanoic acid dicyclohexylammonium salt

: 864167-26-0
benzyl (2S)-1-((2S)-2-((2R,3S)-2-ethoxy-5-oxotetrahydrofuran-3-ylcarbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-ylcarbamate

Guidance literature:: (S)-2-(((benzyloxy)carbonyl)amino)-3,3-dimethylbutanoic acid dicyclohexylammonium salt; With sulfuric acid;

With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In N,N-dimethyl-formamide; for 1h;

C₁₁H₁₈N₂O₄; In N,N-dimethyl-formamide; at 20 ℃; for 8.5h; Further stages.;
DOI:10.1021/ol702532h