2-(Methylthio)thiazolo[4,5-b]pyrazine

Base Information

Chemical Name:2-(Methylthio)thiazolo[4,5-b]pyrazine
CAS No.:87444-23-3
Molecular Formula:C₆H₅N₃S₂
Molecular Weight:183.258
Hs Code.:
Mol file:87444-23-3.mol

Synonyms:2-methylthiothiazolo[4,5-b]pyrazine;2-methylthioquinoxaline;2-methylsulfanyl-quinoxaline;2-(Methylthio)-chinoxalin;2-Methylmercapto-chinoxalin;

Suppliers and Price of 2-(Methylthio)thiazolo[4,5-b]pyrazine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 7 raw suppliers

Chemical Property of 2-(Methylthio)thiazolo[4,5-b]pyrazine

Chemical Property:

Boiling Point:322.2±45.0 °C(Predicted)
PKA:-3.42±0.50(Predicted)
PSA：92.21000
Density:1.48±0.1 g/cm3(Predicted)
LogP:1.80820

Purity/Quality:: ≥95% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 2-(Methylthio)thiazolo[4,5-b]pyrazine

There total 2 articles about 2-(Methylthio)thiazolo[4,5-b]pyrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.5%

: 6863-73-6
3-chloropyrazin-2-amine

: 140-89-6
potassium ethyl xanthogenate

: 74-88-4
methyl iodide

: 87444-23-3
2-methylthiothiazolo<4,5-b>pyrazine

Guidance literature:: 3-chloropyrazin-2-amine; potassium ethyl xanthogenate; In N,N-dimethyl-formamide; for 7h; Inert atmosphere; Reflux;

methyl iodide; In N,N-dimethyl-formamide; at 0 ℃; for 1h;

Reference yield:

: 87444-22-2
thiazolo<4,5-b>pyrazine-2-thiol

: 74-88-4
methyl iodide

: 87444-23-3
2-methylthiothiazolo<4,5-b>pyrazine

Guidance literature:: With sodium hydroxide; for 0.166667h; Yield given;
DOI:10.1071/CH9830983

Reference yield:

: 87444-23-3
2-methylthiothiazolo<4,5-b>pyrazine

: C₆₄H₇₇N₅O₁₄S

Guidance literature:: Multi-step reaction with 3 steps

1: hydrazine hydrate / ethanol / 5 h / 25 °C / Inert atmosphere

2: caesium carbonate / N,N-dimethyl-formamide / 5 h / 25 °C / Inert atmosphere

3: (1S)-10-camphorsulfonic acid / tetrahydrofuran; ethanol / 5 h / 40 °C / Inert atmosphere

With (1S)-10-camphorsulfonic acid; caesium carbonate; hydrazine hydrate; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;