6863-73-6

Basic information

• Product Name: 2-Amino-3-chloropyrazine
• Synonyms: 3-AMINO-2-CHLORO-PYRAZINE;3-AMINO-PYRAZINECHLORIDE;2-AMINO-3-CHLOROPYRAZINE;TIMTEC-BB SBB006510;3-Chloropyrazin-2-amine;3-Chloro-2-pyrazinamine;2-PyrazinaMine, 3-chloro-;3-Chloro-pyrazin-2-ylaMine
• CAS NO: 6863-73-6
• Molecular Formula: C₄H₄ClN₃
• Molecular Weight: 129.55
• Product Categories: Chloropyrazines, etc.;Pyrazines;Chloropyrazin
• Mol File: 6863-73-6.mol
• Article Data: 2

Chemical Properties

• Melting Point: 167-171°C
• Boiling Point: 248.1 °C at 760 mmHg
• Flash Point: 103.8 °C
• Appearance: /
• Density: 1.437 g/cm³
• Vapor Pressure: 0.0248mmHg at 25°C
• Refractive Index: 1.617
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: 2.37±0.10(Predicted)
• Water Solubility: Slightly soluble in water.
• CAS DataBase Reference: 2-Amino-3-chloropyrazine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Amino-3-chloropyrazine(6863-73-6)
• EPA Substance Registry System: 2-Amino-3-chloropyrazine(6863-73-6)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-37
• HazardClass: IRRITANT
• Hazardous Substances Data: 6863-73-6(Hazardous Substances Data)

Usage

Uses

It is employed in the synthesis and tuberculostatic activity of N-pyrazinylthiourea.

InChI:InChI=1/C4H4ClN3/c5-3-4(6)8-2-1-7-3/h1-2H,(H2,6,8)

Upstream product

• 6863-77-0 3-aminopyrazine 1-oxide 
• 5049-61-6 2-Aminopyrazine 

Downstream Products

• 13134-31-1 pyrazine-2,3-diamine 
• 69214-33-1 8-chloroimidazo[1,2-α]pyrazine 
• 212779-11-8 2-Amino-3-(2,3,5-trichlorophenyl)pyrazine 
• 928319-28-2 8-chloro-2-(4-fluorophenyl)imidazo[1,2-a]pyrazine 
• 1400820-06-5 tert-butyl N-(3-chloropyrazin-2-yl)-N-[(2-methylpropan-2-yl)oxycarbonyl]-carbamate 
• 1400820-08-7 (chloropyrazin-2-yl)imino-triphenyl-λ⁵-phosphane 
• 1400820-43-0 (chloropyrazin-2-yl)imino-triphenyl-λ5-phosphane hydrochloride 
• 960116-30-7 8-chloro-2-(4-chlorophenyl)imidazo[1,2-a]pyrazine 
• 1432446-29-1 C₁₂H₆Cl₃N₃ 
• 1427500-64-8 N-phenyl-2-aminothiazolo[4,5-b]pyrazine 
• 1427500-65-9 N-(2-iodophenyl)-2-aminothiazolo[4,5-b]pyrazine 
• 1427500-66-0 N-(2-methoxyphenyl)-2-aminothiazolo[4,5-b]pyrazine 
• 1427500-67-1 N-(3-cyanophenyl)-2-aminothiazolo[4,5-b]pyrazine 
• 1427500-68-2 N-(4-fluorophenyl)-2-aminothiazolo[4,5-b]pyrazine 

Relevant articles and documents

Efficient Halogenation of 2-Aminopyrazine

2-Aminopyrazine was halogenated with NIS, NCS, and NBS under different reaction conditions. Chlorination and bromination were achieved with good yields by using acetonitrile as the solvent. However, iodination was only obtained in poor yields. Undoubtedly, the best conditions for both mono-and dihalogenation were the use of NBS, acetonitrile, and microwave assistance for short periods. 3,5-Dibromo-2-Aminopyrazine is an excellent functionalized starting material for the synthesis of nitrogen heterocycles.