6-(2-Thienyl)-2-pyridinecarboxaldehyde

Base Information

Chemical Name:6-(2-Thienyl)-2-pyridinecarboxaldehyde
CAS No.:208111-00-6
Molecular Formula:C10H7NOS
Molecular Weight:189.23
Hs Code.:2934999090
European Community (EC) Number:624-555-9
DSSTox Substance ID:DTXSID80442040
Nikkaji Number:J3.176.569B
Wikidata:Q82259100
Mol file:208111-00-6.mol

Synonyms:6-(2-Thienyl)-2-pyridinecarboxaldehyde;208111-00-6;6-thiophen-2-ylpyridine-2-carbaldehyde;6-(Thiophen-2-yl)picolinaldehyde;6-(Thiophen-2-yl)pyridine-2-carbaldehyde;6-(2-THIENYL)-2-PYRIDINECARBALDEHYDE;SCHEMBL2030486;DTXSID80442040;MFCD06410007;6-(2-Thienyl)pyridine-2-carbaldehyde;AKOS015960176;AB23847;AS-64809;FT-0692825;6-(2-Thienyl)-2-pyridinecarboxaldehyde, 97%;EN300-7352800;J-013640;Z1255431772

Suppliers and Price of 6-(2-Thienyl)-2-pyridinecarboxaldehyde

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
6-(2-Thienyl)-2-pyridinecarboxaldehyde
100mg
$ 75.00

Sigma-Aldrich
6-(2-Thienyl)-2-pyridinecarboxaldehyde 97%
1g
$ 99.10

Crysdot
6-(Thiophen-2-yl)picolinaldehyde 95+%
10g
$ 470.00

Apolloscientific
6-(2-Thienyl)-2-pyridinecarboxaldehyde 95%
1g
$ 175.00

Alichem
6-(Thiophen-2-yl)picolinaldehyde
10g
$ 498.75

AK Scientific
6-(2-Thienyl)-2-pyridinecarboxaldehyde
1g
$ 175.00

Total 15 raw suppliers

Chemical Property of 6-(2-Thienyl)-2-pyridinecarboxaldehyde

Chemical Property:

Vapor Pressure:0mmHg at 25°C
Melting Point:57-61 °C
Boiling Point:324.663°C at 760 mmHg
PKA:2.72±0.10(Predicted)
Flash Point:150.151°C
PSA：58.20000
Density:1.269g/cm³
LogP:2.62260
XLogP3:2
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:189.02483502
Heavy Atom Count:13
Complexity:186

Purity/Quality:

97% ^*data from raw suppliers

6-(2-Thienyl)-2-pyridinecarboxaldehyde ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xn
Hazard Codes:Xn
Statements: 22-37/38-41
Safety Statements: 26-36

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC(=NC(=C1)C2=CC=CS2)C=O

Technology Process of 6-(2-Thienyl)-2-pyridinecarboxaldehyde

There total 8 articles about 6-(2-Thienyl)-2-pyridinecarboxaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 33674-97-4
6-chloro-2-pyridinemethanol

: 208111-00-6
6-(thien-2-yl)pyridine-2-carboxyaldehyde

Guidance literature:: Multi-step reaction with 7 steps

1: 76.6 percent / DIEA / CH₂Cl₂ / 3 h / Ambient temperature

2: 1.) NaH / 1.) DMF, 0 deg C, 1.5 h, 2.) DMF, 40 deg C, 12 h

3: 76.8 percent / H₂, HCl / Raney Ni / ethanol / 1.5 h / Ambient temperature

4: 75 percent / DMAP / pyridine / 2 h / 0 °C

5: Tl₂CO₃, Pd6H₅)3>4 / benzene / 23 h / Ambient temperature

6: nBuNF, HMPA, 4 Angstroem molecular sieves / tetrahydrofuran / 8 h / Ambient temperature

7: MnO₂ / CH₂Cl₂ / 1 h / Heating

With hydrogenchloride; N,N,N,N,N,N-hexamethylphosphoric triamide; dmap; manganese(IV) oxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; Ti₂CO₃; 4 A molecular sieve; hydrogen; sodium hydride; N-ethyl-N,N-diisopropylamine; nickel; In tetrahydrofuran; pyridine; ethanol; dichloromethane; benzene;
DOI:10.1021/jm9804329

Reference yield:

: 208110-92-3
2-chloro-6-<2-(trimethylsilanyl)ethoxymethoxymethyl>pyridine

: 208111-00-6
6-(thien-2-yl)pyridine-2-carboxyaldehyde

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) NaH / 1.) DMF, 0 deg C, 1.5 h, 2.) DMF, 40 deg C, 12 h

2: 76.8 percent / H₂, HCl / Raney Ni / ethanol / 1.5 h / Ambient temperature

3: 75 percent / DMAP / pyridine / 2 h / 0 °C

4: Tl₂CO₃, Pd6H₅)3>4 / benzene / 23 h / Ambient temperature

5: nBuNF, HMPA, 4 Angstroem molecular sieves / tetrahydrofuran / 8 h / Ambient temperature

6: MnO₂ / CH₂Cl₂ / 1 h / Heating

With hydrogenchloride; N,N,N,N,N,N-hexamethylphosphoric triamide; dmap; manganese(IV) oxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; Ti₂CO₃; 4 A molecular sieve; hydrogen; sodium hydride; nickel; In tetrahydrofuran; pyridine; ethanol; dichloromethane; benzene;
DOI:10.1021/jm9804329

Reference yield:

: 208110-94-5
2-(benzyloxy)-6-<2-(trimethylsilanyl)ethoxymethoxymethyl>pyridine

: 208111-00-6
6-(thien-2-yl)pyridine-2-carboxyaldehyde

Guidance literature:: Multi-step reaction with 5 steps

1: 76.8 percent / H₂, HCl / Raney Ni / ethanol / 1.5 h / Ambient temperature

2: 75 percent / DMAP / pyridine / 2 h / 0 °C

3: Tl₂CO₃, Pd6H₅)3>4 / benzene / 23 h / Ambient temperature

4: nBuNF, HMPA, 4 Angstroem molecular sieves / tetrahydrofuran / 8 h / Ambient temperature

5: MnO₂ / CH₂Cl₂ / 1 h / Heating

With hydrogenchloride; N,N,N,N,N,N-hexamethylphosphoric triamide; dmap; manganese(IV) oxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; Ti₂CO₃; 4 A molecular sieve; hydrogen; nickel; In tetrahydrofuran; pyridine; ethanol; dichloromethane; benzene;
DOI:10.1021/jm9804329