3-(Methylsulfonyl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine

Base Information

• Chemical Name: 3-(Methylsulfonyl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine
• CAS No.: 1206641-26-0
• Molecular Formula: C12H18BNO4S
• Molecular Weight: 283.156
• Hs Code.: 2934999090
• European Community (EC) Number: 691-304-8
• DSSTox Substance ID: DTXSID80694486
• Wikidata: Q82623593
• Mol file: 1206641-26-0.mol

Synonyms:1206641-26-0;3-(methylsulfonyl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine;5-(Methylsulfonyl)pyridine-3-boronic acid pinacol ester;3-methylsulfonyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine;5-(methylsulphonyl)pyridine-3-boronic acid pinacol ester;C12H18BNO4S;SCHEMBL3264039;DTXSID80694486;AMY39744;MFCD12198145;AKOS015950249;MB11715;AS-49790;CS-0046206;FT-0735363;EN300-367212;N10603;J-510894;3-(methylsulfonyl)pyridine-5-boronic acid pinacol ester;Z2044739200;5-(Methylsulfonyl)pyridine-3-boronic acid pinacol ester, AldrichCPR;3-METHANESULFONYL-5-(TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIDINE;3-(Methanesulfonyl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine;3-(methylsulfonyl)-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)pyridine;3-(methylsulfonyl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxab oro lan-2-yl)pyridine

Chemical Property of 3-(Methylsulfonyl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine

Chemical Property:

• Boiling Point: 462.2±45.0 °C(Predicted)
• PKA: 1.67±0.22(Predicted)
• PSA: 73.87000
• Density: 1.21±0.1 g/cm3(Predicted)
• LogP: 1.86510
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 2
• Exact Mass: 283.1049594
• Heavy Atom Count: 19
• Complexity: 427

Purity/Quality:

98%min ^*data from raw suppliers

5-(Methylsulfonyl)pyridine-3-boronic acid pinacol ester ^*data from reagent suppliers

Safty Information:

• Pictogram(s): T
• Hazard Codes: T
• Statements: 25
• Safety Statements: 45

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: B1(OC(C(O1)(C)C)(C)C)C2=CC(=CN=C2)S(=O)(=O)C

Technology Process of 3-(Methylsulfonyl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine

There total 1 articles about 3-(Methylsulfonyl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

5-bromo-3-(methylsulfonyl)pyridine (445491-71-4) + bis(pinacol)diborane (73183-34-3) → 3-(methylsulfonyl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine (1206641-26-0)

Guidance literature:

With potassium acetate; tricyclohexylphosphine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In 1,4-dioxane; at 100 ℃; for 5h;

Reference yield: 20.0%

3-(methylsulfonyl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine (1206641-26-0) + 4-[1-(4-amino-3-methyl-1H-pyrazolo[3,4-d]pyrimidin-1-yl)ethyl]-2-bromo-6-chloro-3-ethoxybenzonitrile (1426699-47-9) → 4-[1-(4-amino-3-methyl-1H-pyrazolo[3,4-d]pyrimidin-1-yl)ethyl]-6-chloro-3-ethoxy-2-[5-(methylsulfonyl)pyridin-3-yl]benzonitrile (1426695-63-7)

Guidance literature:

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate; In water; acetonitrile; at 100 ℃; for 2h; Inert atmosphere;

Reference yield:

3-(methylsulfonyl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine (1206641-26-0) + 4-(di-tert-butylphosphino)-N,N-dimethylaniline-dichloropalladium + 4-bromo-2-cyanopyridine (62150-45-2) → 5-(Methylsulfonyl)-3,4'-bipyridine-2-carbonitrile

Guidance literature:

upstream raw materials:

5-bromo-3-(methylsulfonyl)pyridine

bis(pinacol)diborane

Downstream raw materials:

4-[1-(4-amino-3-methyl-1H-pyrazolo[3,4-d]pyrimidin-1-yl)ethyl]-6-chloro-3-ethoxy-2-[5-(methylsulfonyl)pyridin-3-yl]benzonitrile

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1206641-26-0 3-(Methylsulfonyl)-5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)pyridine

Send

Send

Metric Ton KG G Pound L ML

Send

Send