4-Hydroxymethyl-4'-methyl-2,2'-bipyridyl

Base Information

• Chemical Name: 4-Hydroxymethyl-4'-methyl-2,2'-bipyridyl
• CAS No.: 81998-04-1
• Molecular Formula: C12H12N2O
• Molecular Weight: 200.24
• Hs Code.: 2933399090
• European Community (EC) Number: 805-844-0
• DSSTox Substance ID: DTXSID80373047
• Nikkaji Number: J385.184B
• Wikidata: Q82161158
• Mol file: 81998-04-1.mol

Synonyms:81998-04-1;4-Hydroxymethyl-4'-methyl-2,2'-bipyridyl;(4'-Methyl-[2,2'-bipyridin]-4-yl)methanol;[2-(4-methylpyridin-2-yl)pyridin-4-yl]methanol;4-Hydroxymethyl-4'-methyl-2,2'-bipyridine;4'-Methyl-2,2'-bipyridine-4-methanol;(2-(4-methylpyridin-2-yl)pyridin-4-yl)methanol;{4'-METHYL-[2,2'-BIPYRIDIN]-4-YL}METHANOL;YSWG789;4-(HYDROXYMETHYL)-4'-METHYL-2,2'-BIPYRIDINE;SCHEMBL5468413;DTXSID80373047;AMY22495;MFCD02916382;AKOS004909463;AS-64553;CS-0085998;H1347;T72968;A902536;J-400604;4-Hydroxymethyl-4'-methyl-2,2'-bipyridine 4'-Methyl-2,2'-bipyridine-4-methanol

Chemical Property of 4-Hydroxymethyl-4'-methyl-2,2'-bipyridyl

Chemical Property:

• Melting Point: 119.0 to 123.0 °C
• PSA: 46.01000
• LogP: 1.94430
• Storage Temp.: Inert atmosphere,Room Temperature
• Solubility.: soluble in Methanol
• XLogP3: 1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 200.094963011
• Heavy Atom Count: 15
• Complexity: 198

Purity/Quality:

98% ^*data from raw suppliers

4-Hydroxymethyl-4’-methyl-2,2’-bipyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC(=NC=C1)C2=NC=CC(=C2)CO

Technology Process of 4-Hydroxymethyl-4'-methyl-2,2'-bipyridyl

There total 8 articles about 4-Hydroxymethyl-4'-methyl-2,2'-bipyridyl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

4'-methyl-2,2'-bipyridine-4-carboxylaldehyde (104704-09-8) → 4-(hydroxymethyl)-4'-methyl-2,2'-bipyridine (81998-04-1)

Guidance literature:

With sodium tetrahydroborate; In ethanol; for 1.5h; Ambient temperature;

DOI:10.1246/bcsj.64.1632

Reference yield: 76.0%

4,4'-dimethyl-2,2'-bipyridines (1134-35-6) → 4-(hydroxymethyl)-4'-methyl-2,2'-bipyridine (81998-04-1)

Guidance literature:

4,4'-dimethyl-2,2'-bipyridines; With selenium(IV) oxide; In 1,4-dioxane; at 105 ℃; for 48h; Inert atmosphere;

With sodium tetrahydroborate; sodium hydroxide; In methanol; at 0 - 20 ℃; for 2.5h; Inert atmosphere;

DOI:10.1039/c7ob01249g

Reference yield: 46.1%

4,4’-dimethyl-2,2’-bipyridine N-oxide (81998-03-0) → 4-(hydroxymethyl)-4'-methyl-2,2'-bipyridine (81998-04-1)

Guidance literature:

4,4’-dimethyl-2,2’-bipyridine N-oxide; With acetic anhydride; at 65 ℃; for 17h;

With sodium hydroxide; In ethanol; water; for 0.5h; Reflux;

DOI:10.1016/j.tetlet.2013.07.150

upstream raw materials:

4'-methyl-2,2'-bipyridine-4-carboxylaldehyde

4,4’-dimethyl-2,2’-bipyridine N-oxide

picoline

4,4'-dimethyl-2,2'-bipyridines

Downstream raw materials:

4'-methyl-2,2'-bipyridine-4-carboxylaldehyde

4-bromomethyl-4'-methyl-2,2'-bipyridine

1,2-bis(4′-methyl-[2,2′-bipyridin]-4-yl)ethane