NVP-BKM120 (Hydrochloride)

Base Information

Chemical Name:NVP-BKM120 (Hydrochloride)
CAS No.:1312445-63-8
Molecular Formula:C18H22ClF3N6O2
Molecular Weight:446.8544896
Hs Code.:
Mol file:1312445-63-8.mol

Synonyms:NVP-BKM120 (Hydrochloride);BKM 120 hydrochloride;BKM120 hydrochloride;BKM-120 hydrochloride;5-(2,6-DiMorpholinopyriMidin-4-yl)-4-(trifluoroMethyl)pyridin-2-aMine hydrochloride;5-(2,6-Di-4-morpholinyl-4-pyrimidinyl)-4-(trifluoromethyl)-2-pyridinamine hydrochloride (1:1);BKM 120AAA;Buparlisib hydrochloride

Suppliers and Price of NVP-BKM120 (Hydrochloride)

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

DC Chemicals
NVP-BKM120hydrochloride >98%
50 mg
$ 120.00

DC Chemicals
NVP-BKM120hydrochloride >98%
10 mg
$ 72.00

DC Chemicals
NVP-BKM120hydrochloride >98%
100 mg
$ 200.00

ChemScene
BuparlisibHydrochloride 99.79%
100mg
$ 300.00

ChemScene
BuparlisibHydrochloride 99.79%
50mg
$ 180.00

ChemScene
BuparlisibHydrochloride 99.79%
5mg
$ 72.00

ChemScene
BuparlisibHydrochloride 99.79%
10mg
$ 108.00

Biorbyt Ltd
NVP-BKM120 hydrochloride
100 mg
$ 414.80

Biorbyt Ltd
NVP-BKM120 hydrochloride
50 mg
$ 324.70

Biorbyt Ltd
NVP-BKM120 hydrochloride
10 mg
$ 210.80

Total 32 raw suppliers

Chemical Property of NVP-BKM120 (Hydrochloride)

Chemical Property:

PSA：89.63000
LogP:3.32600
Solubility.:≥44.7 mg/mL in DMSO; ≥52.8 mg/mL in H2O with gentle warming; ≥96 mg/mL in EtOH with gentle warming

Purity/Quality:

99% ^*data from raw suppliers

NVP-BKM120hydrochloride >98% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of NVP-BKM120 (Hydrochloride)

There total 4 articles about NVP-BKM120 (Hydrochloride) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.1%

: 944396-07-0
4-(trifluoromethyl)-5-(2,6-dimorpholinopyrimidin-4-yl)pyridin-2-amine

: 1312445-63-8
5-(2,6-dimorpholin-4-ylpyrimidin-4-yl)-4-trifluoromethylpyridin-2-ylamine hydrochloride

Guidance literature:: With hydrogenchloride; In isopropyl alcohol; acetone; for 2.25h; Product distribution / selectivity; Inert atmosphere;

Reference yield:

: 10244-24-3
2,4-[bis(morpholino)]-6-chloropyrimidine

: 1312445-63-8
5-(2,6-dimorpholin-4-ylpyrimidin-4-yl)-4-trifluoromethylpyridin-2-ylamine hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: potassium acetate / tricyclohexylphosphine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 2 h / 84 °C / Inert atmosphere

2: caesium carbonate / dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II) / water; tetrahydrofuran / 0.75 h / 45 °C / Inert atmosphere

3: hydrogenchloride / isopropyl alcohol; acetone / 2.25 h / Inert atmosphere

With hydrogenchloride; potassium acetate; caesium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II); tricyclohexylphosphine; In tetrahydrofuran; water; isopropyl alcohol; acetone; 2: Suzuki Coupling;

Reference yield:

: 106447-97-6
2-amino-4-(trifluoromethyl)pyridine

: 1312445-63-8
5-(2,6-dimorpholin-4-ylpyrimidin-4-yl)-4-trifluoromethylpyridin-2-ylamine hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: N-Bromosuccinimide / tetrahydrofuran / 2.5 h / 0 - 20 °C / Inert atmosphere

2: caesium carbonate / dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II) / water; tetrahydrofuran / 0.75 h / 45 °C / Inert atmosphere

3: hydrogenchloride / isopropyl alcohol; acetone / 2.25 h / Inert atmosphere

With hydrogenchloride; N-Bromosuccinimide; caesium carbonate; dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II); In tetrahydrofuran; water; isopropyl alcohol; acetone; 2: Suzuki Coupling;