2-AMINO-5-BROMO-4-TRIFLUOROMETHYLPYRIDINE

Base Information

• Chemical Name: 2-AMINO-5-BROMO-4-TRIFLUOROMETHYLPYRIDINE
• CAS No.: 944401-56-3
• Molecular Formula: C6H4BrF3N2
• Molecular Weight: 241.01
• Hs Code.: 29333999
• Mol file: 944401-56-3.mol

Synonyms:2-pyridinamine, 5-bromo-4-(trifluoromethyl)-;

Chemical Property of 2-AMINO-5-BROMO-4-TRIFLUOROMETHYLPYRIDINE

Chemical Property:

• Melting Point: 71-74℃
• Boiling Point: 243.9 °C at 760 mmHg
• PKA: 2.44±0.24(Predicted)
• Flash Point: 101.3 °C
• PSA: 38.91000
• Density: 1.79 g/cm³
• LogP: 3.02630
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• Solubility.: soluble in Methanol

Purity/Quality:

97% ^*data from raw suppliers

2-Amino-5-bromo-4-(trifluoromethyl)pyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 20/21/22-36/37/38-36-22
• Safety Statements: 22-24/25-26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-AMINO-5-BROMO-4-TRIFLUOROMETHYLPYRIDINE

There total 2 articles about 2-AMINO-5-BROMO-4-TRIFLUOROMETHYLPYRIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

→ 2-amino-5-bromo-4-(trifluoromethyl)pyridine (944401-56-3)

Guidance literature:

With N-Bromosuccinimide; In N,N-dimethyl-formamide; at 5 - 20 ℃;

Reference yield: 94.0%

2-amino-4-(trifluoromethyl)pyridine (106447-97-6) → 2-amino-5-bromo-4-(trifluoromethyl)pyridine (944401-56-3)

Guidance literature:

With N-Bromosuccinimide; In dichloromethane; at 25 ℃; for 2h; Darkness;

Reference yield: 94.6%

2-amino-5-bromo-4-(trifluoromethyl)pyridine (944401-56-3) + acetic anhydride (108-24-7) → N-(5-bromo-4-(trifluoromethyl)pyridin-2-yl)acetamide (1370351-46-4)

Guidance literature:

In n-heptane; ethyl acetate; at 0 - 80 ℃; for 10.66h;

upstream raw materials:

2-amino-4-(trifluoromethyl)pyridine

Downstream raw materials:

4-(trifluoromethyl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaboroloan-2-yl)pyridin-2-amine

2-amino-4-(trifluoromethyl)pyridine

N-(5-bromo-4-(trifluoromethyl)pyridin-2-yl)acetamide

5-(2,6-dimorpholin-4-ylpyrimidin-4-yl)-4-trifluoromethylpyridin-2-ylamine hydrochloride