2-chloro-5-(pivalamidomethyl)-N-(8-((3-(trifluoromethyl)phenyl)amino)quinolin-4-yl)benzamide

Base Information

Chemical Name:2-chloro-5-(pivalamidomethyl)-N-(8-((3-(trifluoromethyl)phenyl)amino)quinolin-4-yl)benzamide
CAS No.:1449735-97-0
Molecular Formula:C₂₉H₂₆ClF₃N₄O₂
Molecular Weight:554.999
Hs Code.:

Synonyms:2-chloro-5-(pivalamidomethyl)-N-(8-((3-(trifluoromethyl)phenyl)amino)quinolin-4-yl)benzamide

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Chemical Property of 2-chloro-5-(pivalamidomethyl)-N-(8-((3-(trifluoromethyl)phenyl)amino)quinolin-4-yl)benzamide

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Technology Process of 2-chloro-5-(pivalamidomethyl)-N-(8-((3-(trifluoromethyl)phenyl)amino)quinolin-4-yl)benzamide

There total 9 articles about 2-chloro-5-(pivalamidomethyl)-N-(8-((3-(trifluoromethyl)phenyl)amino)quinolin-4-yl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1427158-97-1
4-nitrophenyl 2-chloro-5-(pivalamidomethyl)benzoate

: 1449736-78-0
N⁸-(3-(trifluoromethyl)phenyl)quinoline-4,8-diamine

: 1449735-97-0
2-chloro-5-(pivalamidomethyl)-N-(8-((3-(trifluoromethyl)phenyl)amino)quinolin-4-yl)benzamide

Guidance literature:: N⁸-(3-(trifluoromethyl)phenyl)quinoline-4,8-diamine; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 0 - 5 ℃; for 0.5h;

4-nitrophenyl 2-chloro-5-(pivalamidomethyl)benzoate; In N,N-dimethyl-formamide; mineral oil; at 0 - 26 ℃; for 2h;

Reference yield:

: 1294496-58-4
2-chloro-5-(pivaloylaminomethyl)benzoic acid

: 1449735-97-0
2-chloro-5-(pivalamidomethyl)-N-(8-((3-(trifluoromethyl)phenyl)amino)quinolin-4-yl)benzamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / water; tetrahydrofuran / 4 h / 20 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 - 5 °C

2.2: 2 h / 0 - 26 °C

With sodium hydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; water; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 35975-57-6
ethyl-8-bromo-4-hydroxyquinolyl-3-carboxylic acid ethyl ester

: 1449735-97-0
2-chloro-5-(pivalamidomethyl)-N-(8-((3-(trifluoromethyl)phenyl)amino)quinolin-4-yl)benzamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: trichlorophosphate / 3 h / 80 °C

2.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 4 h / 120 °C

3.1: lithium hydroxide; water / tetrahydrofuran; methanol / 12 h / 20 °C

4.1: diphenylether / 0.5 h / 240 °C

5.1: tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate / toluene / 0.5 h / 100 °C / Microwave irradiation

6.1: sodium hydrogencarbonate; trifluoroacetic acid / 2 h / 80 °C

7.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 - 5 °C

7.2: 2 h / 0 - 26 °C

With tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; water; sodium hydride; sodium hydrogencarbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; lithium hydroxide; sodium t-butanolate; trichlorophosphate; In tetrahydrofuran; methanol; diphenylether; N,N-dimethyl-formamide; toluene; mineral oil;