Multi-step reaction with 7 steps
1.1: trichlorophosphate / 3 h / 80 °C
2.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 4 h / 120 °C
3.1: lithium hydroxide; water / tetrahydrofuran; methanol / 12 h / 20 °C
4.1: diphenylether / 0.5 h / 240 °C
5.1: tris(dibenzylideneacetone)dipalladium (0); 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate / toluene / 0.5 h / 100 °C / Microwave irradiation
6.1: sodium hydrogencarbonate; trifluoroacetic acid / 2 h / 80 °C
7.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 - 5 °C
7.2: 2 h / 0 - 26 °C
With
tris(dibenzylideneacetone)dipalladium (0); water; sodium hydride; sodium hydrogencarbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; lithium hydroxide; sodium t-butanolate; trichlorophosphate;
In
tetrahydrofuran; methanol; diphenylether; N,N-dimethyl-formamide; toluene; mineral oil;