Ethyl 4-amino-6-chloro-5-nitronicotinate

Base Information

• Chemical Name: Ethyl 4-amino-6-chloro-5-nitronicotinate
• CAS No.: 690635-35-9
• Molecular Formula: C8H8ClN3O4
• Molecular Weight: 245.62
• Hs Code.: 2933399090
• Mol file: 690635-35-9.mol

Synonyms:ethylaminochloronitronicotinate;4-Amino-6-chloro-5-nitro-pyridine-3-carboxylic acid ethyl ester;ethyl 4-amino-6-chloro-5-nitronicotinate;

Chemical Property of Ethyl 4-amino-6-chloro-5-nitronicotinate

Chemical Property:

• PSA: 111.03000
• LogP: 2.50650
• Storage Temp.: Sealed in dry,Store in freezer, under -20°C

Purity/Quality:

98%min ^*data from raw suppliers

Ethyl 4-amino-6-chloro-5-nitronicotinate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Ethyl 4-amino-6-chloro-5-nitronicotinate

There total 4 articles about Ethyl 4-amino-6-chloro-5-nitronicotinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.6%

ethyl 2,4-dichloro-3-nitropyridine-5-carboxylate (154012-15-4) → ethyl 4-amino-6-chloro-5-nitronicotinate (690635-35-9)

Guidance literature:

With ammonia; In 1,4-dioxane; dichloromethane; at 0 - 20 ℃; for 24h;

DOI:10.1016/j.bmc.2015.09.026

Reference yield:

diethyl 1,3-acetonedicarboxylate (105-50-0) → ethyl 4-amino-6-chloro-5-nitronicotinate (690635-35-9)

Guidance literature:

Multi-step reaction with 4 steps

1.1: acetic anhydride / 3 h / 130 °C

1.2: 0.5 h / 20 °C

2.1: nitric acid; sulfuric acid / 0 - 20 °C

3.1: trichlorophosphate / 24 h / 80 °C

4.1: ammonia / dichloromethane; 1,4-dioxane / 24 h / 0 - 20 °C

With sulfuric acid; ammonia; nitric acid; acetic anhydride; trichlorophosphate; In 1,4-dioxane; dichloromethane;

DOI:10.1016/j.bmc.2015.09.026

Reference yield:

4,6-dihydroxynicotinic acid ethyl ester (6975-44-6) → ethyl 4-amino-6-chloro-5-nitronicotinate (690635-35-9)

Guidance literature:

Multi-step reaction with 3 steps

1: nitric acid; sulfuric acid / 0 - 20 °C

2: trichlorophosphate / 24 h / 80 °C

3: ammonia / dichloromethane; 1,4-dioxane / 24 h / 0 - 20 °C

With sulfuric acid; ammonia; nitric acid; trichlorophosphate; In 1,4-dioxane; dichloromethane;

DOI:10.1016/j.bmc.2015.09.026

upstream raw materials:

ethyl 2,4-dichloro-3-nitropyridine-5-carboxylate

diethyl 1,3-acetonedicarboxylate

4,6-dihydroxynicotinic acid ethyl ester

ethyl 2,4-dihydroxy-3-nitropyridine-5-carboxylate

Downstream raw materials:

4-amino-6-bis(phenylmethyl)amino-5-nitro-pyridine-3-carboxylic acid ethyl ester

Refernces

• 1、 -. "Antiinflammation agents". Page/Page column 24-25. . Retrieved 2010/02/06.