Methyl 2-fluoro-4-iodobenzoate

Base Information

• Chemical Name: Methyl 2-fluoro-4-iodobenzoate
• CAS No.: 204257-72-7
• Molecular Formula: C8H6FIO2
• Molecular Weight: 280.037
• Hs Code.: 2916399090
• Mol file: 204257-72-7.mol

Synonyms:Methyl 2-fluoro-4-iodobenzoate;

Chemical Property of Methyl 2-fluoro-4-iodobenzoate

Chemical Property:

• Vapor Pressure: 0.003mmHg at 25°C
• Boiling Point: 284.109°C at 760 mmHg
• Flash Point: 125.625°C
• PSA: 26.30000
• Density: 1.823g/cm³
• LogP: 2.21690
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

Methyl 2-fluoro-4-iodobenzoate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Methyl 2-fluoro-4-iodobenzoate

There total 3 articles about Methyl 2-fluoro-4-iodobenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

methanol (67-56-1) + 2-fluoro-4-iodo-benzoic acid (124700-40-9) → methyl-2-fluoro-4-iodo-benzoate (204257-72-7)

Guidance literature:

With thionyl chloride; at 0 - 85 ℃; for 1h;

Reference yield: 94.0%

2-fluoro-4-iodo-benzoic acid (124700-40-9) → methyl-2-fluoro-4-iodo-benzoate (204257-72-7)

Guidance literature:

With thionyl chloride; In methanol; at 0 - 85 ℃; for 1h;

DOI:10.1021/acs.jmedchem.6b00812

Reference yield: 5.0%

2-fluoro-4-iodotoluene (39998-81-7) → methyl-2-fluoro-4-iodo-benzoate (204257-72-7)

Guidance literature:

With potassium permanganate; sulfuric acid; In pyridine; methanol; diethyl ether; hexane; water;

upstream raw materials:

methanol

2-fluoro-4-iodo-benzoic acid

2-fluoro-4-iodotoluene

Downstream raw materials:

2-fluoro-4-(2,2,4,4-tetramethyl-chroman-6-yl-ethynyl)-benzoic acid methyl ester

2-fluoro-4-(2-oxo-2H-pyridin-1-yl)-benzoic acid methyl ester

4-{3-[(2S,3R,4S,5R)-4-(3-chloro-2-fluoro-phenyl)-3-(4-chloro-2-fluoro-phenyl)-3-cyano-2-(2,2-dimethyl-propyl)-5-hydroxymethyl-pyrrolidin-1-yl]-prop-1-ynyl}-2-fluoro-benzoic acid

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