tert-Butyl4-(cyano(phenyl)methyl)piperazine-1-carboxylate

Base Information

• Chemical Name: tert-Butyl4-(cyano(phenyl)methyl)piperazine-1-carboxylate
• CAS No.: 444891-21-8
• Molecular Formula: C17H23N3O2
• Molecular Weight: 301.38
• Hs Code.: 2933599090
• Mol file: 444891-21-8.mol

Synonyms:TERT-BUTYL4-(CYANO(PHENYL)METHYL)PIPERAZINE-1-CARBOXYLATE

Chemical Property of tert-Butyl4-(cyano(phenyl)methyl)piperazine-1-carboxylate

Chemical Property:

• PSA: 56.57000
• LogP: 2.67978

Purity/Quality:

97% ^*data from raw suppliers

tert-Butyl4-(cyano(phenyl)methyl)piperazine-1-carboxylate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of tert-Butyl4-(cyano(phenyl)methyl)piperazine-1-carboxylate

There total 4 articles about tert-Butyl4-(cyano(phenyl)methyl)piperazine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

4-benzoylpiperazine-1-carboxylic acid tert-butyl ester (77278-38-7) → tert-butyl 4-(cyano(phenyl)methyl)piperazine-1-carboxylate (444891-21-8)

Guidance literature:

4-benzoylpiperazine-1-carboxylic acid tert-butyl ester; With bis(triphenylphosphine)iridium(I) carbonyl chloride; In toluene; at 20 ℃; for 0.0833333h;

With 1,1,3,3-Tetramethyldisiloxane; In toluene; at 20 ℃; for 0.0833333h;

With trimethylsilyl cyanide; In toluene; at 20 ℃; for 0.5h;

DOI:10.1002/anie.201612367

Reference yield:

potassium cyanide (151-50-8) + benzaldehyde (100-52-7) + 1-t-Butoxycarbonylpiperazine (57260-71-6) → tert-butyl 4-(cyano(phenyl)methyl)piperazine-1-carboxylate (444891-21-8)

Guidance literature:

benzaldehyde; 1-t-Butoxycarbonylpiperazine; With sodium hydrogensulfite; In methanol; water;

potassium cyanide; In methanol; water; at 20 ℃; for 24h;

Reference yield:

potassium cyanide + benzaldehyde (100-52-7) + 1-t-Butoxycarbonylpiperazine (57260-71-6) → tert-butyl 4-(cyano(phenyl)methyl)piperazine-1-carboxylate (444891-21-8)

Guidance literature:

With sodium hydrogensulfite; In methanol; water; at 0 - 20 ℃; for 12h;

upstream raw materials:

potassium cyanide

benzaldehyde

1-t-Butoxycarbonylpiperazine

4-benzoylpiperazine-1-carboxylic acid tert-butyl ester