5-Bromo-3-chloro-2-pyridinecarboxylic acid methyl ester

Base Information

• Chemical Name: 5-Bromo-3-chloro-2-pyridinecarboxylic acid methyl ester
• CAS No.: 1214336-41-0
• Molecular Formula: C7H5BrClNO2
• Molecular Weight: 250
• Hs Code.: 2933399090
• Mol file: 1214336-41-0.mol

Synonyms:5-Bromo-3-chloro-2-pyridinecarboxylic acid methyl ester;Methyl 5-broMo-3-chloropicolinate;Methyl 5-broMo-3-chloropyridine-2-carboxylate

Chemical Property of 5-Bromo-3-chloro-2-pyridinecarboxylic acid methyl ester

Chemical Property:

• Boiling Point: 311℃
• PKA: -3.26±0.10(Predicted)
• Flash Point: 142℃
• PSA: 39.19000
• Density: 1.684
• LogP: 2.28410
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

99%, ^*data from raw suppliers

5-Bromo-3-chloro-2-pyridinecarboxylicAcidMethylEster ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 5-Bromo-3-chloro-2-pyridinecarboxylic Acid Methyl Ester is an intermediate used to prepare aminopyridinyldihydrooxazine derivatives for use as BACE-1 and/or BACE-2 inhibitors.

Technology Process of 5-Bromo-3-chloro-2-pyridinecarboxylic acid methyl ester

There total 3 articles about 5-Bromo-3-chloro-2-pyridinecarboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methanol (67-56-1) + 5-bromo-3-chloro-pyridine-2-carboxylic acid (1189513-51-6) → 3-chloro-5-bromo-pyridine-2-carboxylic acid methyl ester (1214336-41-0)

Guidance literature:

With thionyl chloride; for 1.5h; Reflux;

Reference yield:

methanol (67-56-1) + 5-bromo-3-chloro-pyridine-2-carbonyl chloride → 3-chloro-5-bromo-pyridine-2-carboxylic acid methyl ester (1214336-41-0)

Guidance literature:

In dichloromethane; at 10 - 20 ℃;

Reference yield:

5-bromo-3-chloro-pyridine-2-carboxylic acid (1189513-51-6) → 3-chloro-5-bromo-pyridine-2-carboxylic acid methyl ester (1214336-41-0)

Guidance literature:

Multi-step reaction with 2 steps

1: N,N-dimethyl-formamide; oxalyl dichloride / dichloromethane / 3 h / 20 °C

2: dichloromethane / 10 - 20 °C

With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane;

upstream raw materials:

methanol

5-bromo-3-chloro-pyridine-2-carboxylic acid

Downstream raw materials:

5-bromo-3-chloro-pyridine-2-carboxylic acid

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