4-(2-hydroxypropan-2-yl)phenylboronic acid

Base Information

• Chemical Name: 4-(2-hydroxypropan-2-yl)phenylboronic acid
• CAS No.: 886593-45-9
• Molecular Formula: C9H13BO3
• Molecular Weight: 180.011
• Hs Code.: 2931900090
• Mol file: 886593-45-9.mol

Synonyms:4-(2-hydroxypropan-2-yl)phenylboronic acid;4-(2-Hydroxy-2-propanyl)phenylboronic Acid

Chemical Property of 4-(2-hydroxypropan-2-yl)phenylboronic acid

Chemical Property:

• Boiling Point: 354.4±44.0 °C(Predicted)
• PKA: 8.66±0.17(Predicted)
• PSA: 60.69000
• Density: 1.16±0.1 g/cm3(Predicted)
• LogP: -0.40620
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

4-(2-Hydroxypropan-2-yl)phenylboronicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(2-hydroxypropan-2-yl)phenylboronic acid

There total 2 articles about 4-(2-hydroxypropan-2-yl)phenylboronic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 13.0%

Triisopropyl borate (5419-55-6) + 2-(4-bromophenyl)propan-2-ol (2077-19-2) → (4-(2-hydroxypropan-2-yl)phenyl)boronic acid (886593-45-9)

Guidance literature:

2-(4-bromophenyl)propan-2-ol; With n-butyllithium; In tetrahydrofuran; hexanes; at -78 ℃; for 3.5h;

Triisopropyl borate; In tetrahydrofuran; hexanes; at 20 ℃; for 72h;

Reference yield:

methylmagnesium chloride (676-58-4) + 4-acetylphenylboronic acid (149104-90-5) → (4-(2-hydroxypropan-2-yl)phenyl)boronic acid (886593-45-9)

Guidance literature:

methylmagnesium chloride; 4-acetylphenylboronic acid; In diethyl ether; at 20 ℃; for 0.5h;

With hydrogenchloride; In diethyl ether; water;

Reference yield: 71.0%

(4-(2-hydroxypropan-2-yl)phenyl)boronic acid (886593-45-9) + 1,5-anhydro-3,4,6-tri-O-benzyl-1,2-dideoxy-1-phenylsulfonyl-D-arabino-hex-1-enitol (64978-35-4) → 1-(4-(2-hydroxypropan-2-yl)phenyl)-3,4,6-tri-O-benzyl-D-glucal

Guidance literature:

With bis(1,5-cyclooctadiene)nickel ⁽⁰⁾; tricyclohexylphosphine tetrafluoroborate; potassium hydroxide; In tert-butyl alcohol; at 60 ℃; for 12h; chemoselective reaction; Sealed tube;

DOI:10.1021/jacs.9b02312 DOI:10.1021/jacs.9b02312

upstream raw materials:

methylmagnesium chloride

4-acetylphenylboronic acid

Triisopropyl borate

2-(4-bromophenyl)propan-2-ol

Downstream raw materials:

5-(4-(1-hydroxy-1-methylethyl)phenyl)-2-({6-(morpholin-4-ylmethyl)pyridin-2-yl}amino)thiophene-3-carboxamide

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