5-Bromo-4-chloro-1H-benzo[d]imidazole

Base Information

• Chemical Name: 5-Bromo-4-chloro-1H-benzo[d]imidazole
• CAS No.: 1008361-81-6
• Molecular Formula: C7H4BrClN2
• Molecular Weight: 231.47706
• Hs Code.: 2933998090
• Mol file: 1008361-81-6.mol

Synonyms:5-bromo-4-chloro-1H-benzimidazole;6-Bromo-7-chloro-1H-benzimidazole;5-Bromo-4-chloro-1H-benzoimidazole;1H-Benzimidazole, 6-Bromo-7-Chloro-;6-bromo-7-chloro-1H-benzo[d]imidazole;5-broMo-4-chloro-1H-benzo[d]iMidazole;1H-Benzimidazole, 6-Bromo-7-Chloro-(WX637283)

Chemical Property of 5-Bromo-4-chloro-1H-benzo[d]imidazole

Chemical Property:

• Boiling Point: 454.3±25.0 °C(Predicted)
• PKA: 8.74±0.30(Predicted)
• PSA: 0.00000
• Density: 1.878±0.06 g/cm3(Predicted)
• LogP: 0.00000
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

5-Bromo-4-chloro-1H-benzoimidazole 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-Bromo-4-chloro-1H-benzo[d]imidazole

There total 1 articles about 5-Bromo-4-chloro-1H-benzo[d]imidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

formic acid (64-18-6) + 4-bromo-3-chloro-benzene-1,2-diamine (1008361-80-5) → 5-bromo-4-chloro-1H-benzoimidazole (1008361-81-6)

Guidance literature:

for 1.5h; Reflux;

Reference yield:

5-bromo-4-chloro-1H-benzoimidazole (1008361-81-6) → N-((4-chloro-1-(tetrahydro-2H-pyran-2-yl)-1H-benzo[d]imidazol-5-yl)methyl)ethanamine dihydrochloride

Guidance literature:

Multi-step reaction with 6 steps

1.1: camphor-10-sulfonic acid / tetrahydrofuran / 16 h / 60 °C

2.1: 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / N,N-dimethyl-formamide / 6 h / 110 °C

3.1: nickel; hydrogen; ammonia / methanol / 16 h

4.1: sodium hydroxide / tetrahydrofuran; water / 16 h / 0 - 23 °C

5.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.42 h / 0 - 23 °C

5.2: 6 h / 0 - 23 °C

6.1: hydrogenchloride / 1,4-dioxane; methanol / 2 h / 23 °C

With hydrogenchloride; 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; camphor-10-sulfonic acid; ammonia; hydrogen; nickel; sodium hydride; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; water; N,N-dimethyl-formamide; mineral oil;

DOI:10.1021/acs.jmedchem.5b00572

upstream raw materials:

formic acid

4-bromo-3-chloro-benzene-1,2-diamine

Refernces

• 1、 -. "SERINE/THREONINE PAK1 INHIBITORS". Page/Page column 136. . Retrieved 2013/03/26.