5-(1-(6-Chloro-5-nitropyrimidin-4-yl)piperidin-4-yl)-3-isopropyl-1,2,4-oxadiazole

Base Information

• Chemical Name: 5-(1-(6-Chloro-5-nitropyrimidin-4-yl)piperidin-4-yl)-3-isopropyl-1,2,4-oxadiazole
• CAS No.: 1054579-82-6
• Molecular Formula: C14 H17 ClN6 O3
• Molecular Weight: 352.78
• Mol file: 1054579-82-6.mol

Synonyms:5-(1-(6-CHLORO-5-NITROPYRIMIDIN-4-YL)PIPERIDIN-4-YL)-3-ISOPROPYL-1,2,4-OXADIAZOLE;

Chemical Property of 5-(1-(6-Chloro-5-nitropyrimidin-4-yl)piperidin-4-yl)-3-isopropyl-1,2,4-oxadiazole

Chemical Property:

• PSA: 113.76000
• LogP: 3.51680

Purity/Quality:

5-(1-(6-CHLORO-5-NITROPYRIMIDIN-4-YL)PIPERIDIN-4-YL)-3-ISOPROPYL-1,2,4-OXADIAZOLE 95.00% ^*data from reagent suppliers

Safty Information:

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Technology Process of 5-(1-(6-Chloro-5-nitropyrimidin-4-yl)piperidin-4-yl)-3-isopropyl-1,2,4-oxadiazole

There total 2 articles about 5-(1-(6-Chloro-5-nitropyrimidin-4-yl)piperidin-4-yl)-3-isopropyl-1,2,4-oxadiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

4-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidine hydrochloride (733751-26-3) + 2,4-Dichloro-5-nitropyrimidine (49845-33-2) → 5-(1-(6-chloro-5-nitropyrimidin-4-yl)piperidin-4-yl)-3-isopropyl-1,2,4-oxadiazole (1054579-82-6)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 ℃; for 2h;

DOI:10.1021/jm8006867

Reference yield: 62.0%

4,6-dichloro-5-nitropyrimidine (4316-93-2) + 3-isopropyl-5-(piperidin-4-yl)-1,2,4-oxadiazole hydrochloride salt → 5-(1-(6-chloro-5-nitropyrimidin-4-yl)piperidin-4-yl)-3-isopropyl-1,2,4-oxadiazole (1054579-82-6)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 27 ℃; for 4h; Cooling with ice;

Reference yield: 76.0%

5-(1-(6-chloro-5-nitropyrimidin-4-yl)piperidin-4-yl)-3-isopropyl-1,2,4-oxadiazole (1054579-82-6) + 4-methanesulfonylphenylamine (5470-49-5) → {6-[4-(3-isopropyl-[1,2,4]oxadiazol-5-yl)-piperidin-1-yl]-5-nitro-pyrimidin-4-yl}-(4-methanesulfonylphenyl)-amine (733751-02-5)

Guidance literature:

With potassium carbonate; In 1,4-dioxane; at 250 ℃; for 0.0833333h; Microwave irradiation;

DOI:10.1021/jm8006867

upstream raw materials:

4-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidine hydrochloride

2,4-Dichloro-5-nitropyrimidine

4,6-dichloro-5-nitropyrimidine

Downstream raw materials:

(2-fluoro-4-methanesulfonyl-phenyl)-{6-[4-(3-isopropyl-[1,2,4]oxadiazol-5-yl)-piperidin-1-yl]-5-nitro-pyrimidin-4-yl}-amine

{6-[4-(3-isopropyl-[1,2,4]oxadiazol-5-yl)-piperidin-1-yl]-5-nitro-pyrimidin-4-yl}-(4-methanesulfonylphenyl)-amine

N-(4-(ethylsulfonyl)phenyl)-6-(4-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-1-yl)-5-nitropyrimidin-4-amine

6-(4-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-1-yl)-N-(4-(isopropylsulfonyl)phenyl)-5-nitropyrimidin-4-amine

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