Benzyl Spiro[indole-3,4'-piperidine]-1'-carboxylate

Base Information

Chemical Name:Benzyl Spiro[indole-3,4'-piperidine]-1'-carboxylate
CAS No.:184289-85-8
Molecular Formula:C20H20N2O2
Molecular Weight:320.391
Hs Code.:
DSSTox Substance ID:DTXSID40452786
Wikidata:Q82273612
Mol file:184289-85-8.mol

Synonyms:Benzyl Spiro[indole-3,4'-piperidine]-1'-carboxylate;184289-85-8;benzyl spiro[indole-3,4/'-piperidine]-1/'-carboxylate;DTXSID40452786;URTAFWBDASBETD-UHFFFAOYSA-N;CS-0449224;F14000;BenzylSpiro[indole-3,4'-piperidine]-1'-carboxylate

Suppliers and Price of Benzyl Spiro[indole-3,4'-piperidine]-1'-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
Benzylspiro[indole-3,4'-piperidine]-1'-carboxylate 95+%
1g
$ 451.00

Chemenu
benzylspiro[indole-3,4''-piperidine]-1''-carboxylate 95%
1g
$ 426.00

American Custom Chemicals Corporation
BENZYL SPIRO[INDOLE-3,4'-PIPERIDINE]-1'-CARBOXYLATE 95.00%
5MG
$ 502.37

Alichem
Benzylspiro[indole-3,4'-piperidine]-1'-carboxylate
1g
$ 464.10

Total 8 raw suppliers

Chemical Property of Benzyl Spiro[indole-3,4'-piperidine]-1'-carboxylate

Chemical Property:

PSA：41.90000
LogP:3.44640
Storage Temp.:2-8°C
XLogP3:2.8
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:320.152477885
Heavy Atom Count:24
Complexity:476

Purity/Quality:

97% ^*data from raw suppliers

Benzylspiro[indole-3,4'-piperidine]-1'-carboxylate 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CN(CCC12C=NC3=CC=CC=C23)C(=O)OCC4=CC=CC=C4

Technology Process of Benzyl Spiro[indole-3,4'-piperidine]-1'-carboxylate

There total 8 articles about Benzyl Spiro[indole-3,4'-piperidine]-1'-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 138163-08-3
N-(benzyloxycarbonyl)piperidine-4-carboxaldehyde

: 100-63-0
phenylhydrazine

: 184289-85-8
benzyl spiro[indole-3,4'-piperidine]-1'-carboxylate

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 35 ℃; for 17h;
DOI:10.1016/S0040-4020(97)00359-1

Reference yield: 54.0%

: 59-88-1
phenylhydrazine hydrochloride

: 138163-08-3
N-(benzyloxycarbonyl)piperidine-4-carboxaldehyde

: 184289-85-8
benzyl spiro[indole-3,4'-piperidine]-1'-carboxylate

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 0 - 20 ℃; for 17h;
DOI:10.1055/s-0036-1588084

Reference yield:

: 498-94-2
isonipecotic acid

: 184289-85-8
benzyl spiro[indole-3,4'-piperidine]-1'-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: 97 percent / K₂CO₃ / H₂O / 58 h / 22 °C

2: (COCl)2 / toluene; dimethylformamide / 16 h / 18 °C

3: 94 percent / H₂, DIEA, thioanisole / Pd/C / toluene / 22 h / 20 °C / 2068.6 Torr

4: 99 percent / TFA / CH₂Cl₂ / 17 h / 35 °C

With oxalyl dichloride; methyl-phenyl-thioether; hydrogen; potassium carbonate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; palladium on activated charcoal; In dichloromethane; water; N,N-dimethyl-formamide; toluene;
DOI:10.1016/S0040-4020(97)00359-1