(1-(benzofuran-5-yl)-N-Methylpropan-2-aMine

Base Information

• Chemical Name: (1-(benzofuran-5-yl)-N-Methylpropan-2-aMine
• CAS No.: 1354631-77-8
• Molecular Formula: C12H15NO
• Molecular Weight: 189.25
• Mol file: 1354631-77-8.mol

Synonyms:1-(Benzofuran-5-yl)-N-methylpropan-2-amine;

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Chemical Property of (1-(benzofuran-5-yl)-N-Methylpropan-2-aMine

Chemical Property:

• Boiling Point: 279.8±15.0 oC (760 Torr), Calc.*
• PKA: 10.26±0.10(Predicted)
• Flash Point: 123.0±20.4 oC, Calc.*
• PSA: 25.17000
• Density: 1.043±0.06 g/cm3 (20 oC 760 Torr), Calc.*
• LogP: 2.97410

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (1-(benzofuran-5-yl)-N-Methylpropan-2-aMine

There total 2 articles about (1-(benzofuran-5-yl)-N-Methylpropan-2-aMine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

1-(benzofuran-5-yl)propan-2-one (286836-32-6) + methylamine (74-89-5) → 1-(benzofuran-5-yl)-N-methylpropan-2-amine (1354631-77-8)

Guidance literature:

1-(benzofuran-5-yl)propan-2-one; methylamine; With acetic acid; In tetrahydrofuran; at 20 ℃; for 1h;

With sodium tris(acetoxy)borohydride; In tetrahydrofuran; at 20 ℃; for 16h;

Reference yield:

5-bromobenzofuran (23145-07-5) → 1-(benzofuran-5-yl)-N-methylpropan-2-amine (1354631-77-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: tributyltin methoxide; palladium dichloride; tris-(o-tolyl)phosphine / toluene / 16 h / 100 °C / Inert atmosphere

2.1: acetic acid / tetrahydrofuran / 1 h / 20 °C

2.2: 16 h / 20 °C

With tributyltin methoxide; acetic acid; tris-(o-tolyl)phosphine; palladium dichloride; In tetrahydrofuran; toluene;

upstream raw materials:

5-bromobenzofuran

1-(benzofuran-5-yl)propan-2-one

methylamine