Benzamide, 2-amino-4-hydroxy- (9CI)

Base Information

• Chemical Name: Benzamide, 2-amino-4-hydroxy- (9CI)
• CAS No.: 82049-00-1
• Molecular Formula: C7H8N2O2
• Molecular Weight: 152.153
• Mol file: 82049-00-1.mol

Synonyms:Benzamide, 2-amino-4-hydroxy- (9CI);2-aMino-4-hydroxybenzaMide

Chemical Property of Benzamide, 2-amino-4-hydroxy- (9CI)

Chemical Property:

• Boiling Point: 353.6±27.0 °C(Predicted)
• PKA: 8.70±0.18(Predicted)
• Density: 1.397±0.06 g/cm3(Predicted)
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature

Purity/Quality:

97% ^*data from raw suppliers

2-Amino-4-hydroxybenzamide 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzamide, 2-amino-4-hydroxy- (9CI)

There total 2 articles about Benzamide, 2-amino-4-hydroxy- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-amino-p-anisamide (38487-91-1) → 2-amino-4-hydroxybenzamide (82049-00-1)

Guidance literature:

2-amino-p-anisamide; With boron tribromide; In tetrahydrofuran; 1,2-dichloro-ethane; at 20 - 50 ℃;

With sodium hydrogencarbonate; In tetrahydrofuran; water; 1,2-dichloro-ethane;

Reference yield:

aq. sodium bicarbonate + 2-amino-p-anisamide (38487-91-1) → 2-amino-4-hydroxybenzamide (82049-00-1)

Guidance literature:

With boron tribromide; In tetrahydrofuran; 1,2-dichloro-ethane;

Reference yield: 43.0%

2-amino-4-hydroxybenzamide (82049-00-1) + benzyl bromide (100-39-0) → 2-amino-4-(benzyloxy)benzamide (1241915-51-4)

Guidance literature:

2-amino-4-hydroxybenzamide; With sodium hydride; In N,N-dimethyl-formamide; at 10 - 40 ℃;

benzyl bromide; In N,N-dimethyl-formamide; at 10 - 20 ℃;

upstream raw materials:

2-amino-p-anisamide

Downstream raw materials:

2-amino-4-(benzyloxy)benzamide

4-(benzyloxy)-2-(2-(4-fluorophenyl)-2-hydroxyacetamido)benzamide

Refernces

• 1、 -. "JAK KINASE MODULATING QUINAZOLINE DERIVATIVES AND METHODS OF USE THEREOF". Page/Page column 123-124. . Retrieved 2010/09/17.