38487-91-1

Usage

Uses

Used in Pharmaceutical Industry:
2-Amino-4-methoxybenzamide is used as a building block for the synthesis of pharmaceutical drugs due to its versatile chemical structure and potential therapeutic properties, such as anti-inflammatory and analgesic effects. It serves as a valuable component in the development of new medications for various health conditions.
Used in Agrochemical Industry:
AMB is used as a building block in the synthesis of agrochemicals, contributing to the development of effective and environmentally friendly products for agricultural applications.
Used in Dye and Pigment Production:
2-Amino-4-methoxybenzamide is used as a key intermediate in the production of dyes and pigments, providing a foundation for the creation of a wide range of colorants used in various industries, including textiles, plastics, and printing.
Used in Organic Synthesis:
As an important compound in organic synthesis, 2-Amino-4-methoxybenzamide is used as an intermediate in the production of various chemicals, playing a crucial role in the synthesis of complex organic molecules and contributing to the advancement of chemical research and development.

InChI:InChI=1/C8H10N2O2/c1-12-5-2-3-6(8(10)11)7(9)4-5/h2-4H,9H2,1H3,(H2,10,11)

Upstream product

• 33844-22-3 4-methoxy-2-nitro-benzoic acid amide 
• 38469-83-9 4-methoxy-2-nitro-benzonitrile 
• 52351-75-4 6-methoxyisatin 
• 128076-63-1 7-methoxy-2H-benzo[d][1,3]oxazine-2,4(1H)-dione 
• 4294-95-5 4-methoxyanthranilic acid 
• 33844-21-2 2-nitro-4-methoxybenzoic acid 

Downstream Products

• 16064-24-7 7-methoxyquinazoline-4(3H)-one 
• 54166-80-2 ethyl ((2-(aminocarbonyl)-5-methoxyphenyl)amino)(oxo)acetate 
• 246231-75-4 7-methoxy-2-phenylquinazolin-4(3H)-one 
• 4294-95-5 4-methoxyanthranilic acid 
• 82049-00-1 2-amino-4-hydroxybenzamide 
• 1241914-99-7 2-(2,2-difluoro-2-(4-fluorophenyl)acetamido)-4-methoxybenzamide 
• 1319212-86-6 2-{4,6-bis(isobutylamino)-[1,3,5]triazin-2-ylamino}-4-methoxybenzamide 
• 1246250-42-9 2-[4-(2-hydroxy-ethoxy)-3,5-dimethyl-phenyl]-7-methoxy-3H-quinazolin-4-one 
• 1224442-45-8 2-(4-methylphenyl)-7-methoxyquinazolin-4(3H)-one 
• 1610372-92-3 2-(5-(2-(Isopropylamino)ethoxy)-6-(4-(methylsulfinyl)phenyl)pyridin-2-yl)-7-methoxyquinazolin-4(3H)-one 
• 1610373-99-3 2-((6-(7-methoxy-4-oxo-3,4-dihydroquinazolin-2-yl)-2-(4-(methylsulfinyl)phenyl)pyridin-3-yl)oxy)ethyl methanesulfonate 
• 1610372-86-5 2-(5-(2-hydroxyethoxy)-6-(4-(methylsulfinyl)phenyl)pyridin-2-yl)-7-methoxyquinazolin-4(3H)-one 

Relevant academic research and scientific papers

Allylamine derivative as well as preparation method and application thereof

The invention relates to an allylamine derivative as well as a preparation method and application thereof, and in particular, relates to a compound represented by a formula I, or a stereoisomer, a tautomer, a polymorphic substance, a solvate, an N-oxide, an isotope labeled compound, a metabolite, a prodrug or ester thereof, or a pharmaceutically acceptable salt thereof. The compound has a higher inhibitory activity against vascular adhesion protein 1/semicarbazide sensitive amine oxidase, a good selectivity against monoamine oxidase and diamine oxidase; and additionally, in some embodiments, the mixture has a high in vivo bioavailability as well as safety.

Synthesis and nematicidal activities of 1,2,3-benzotriazin-4-one containing 4,5-dihydrothiazole-2-thiol derivatives against Meloidogyne incognita

A series of novel 1,2,3-benzotriazin-4-one derivatives containing 4,5-dihydrothiazole-2-thiol were synthesized and characterized by 1H NMR, 13C NMR, 19F NMR and HRMS. The bioassay results showed that compounds 3-(3-((4,5-dihydrothiazol-2-yl)thio)propyl)-7-methoxybenzo[d][1–3]triazin-4(3H)-one, 3-(3-((4,5-dihydrothiazol-2-yl)thio)propyl)-6-nitrobenzo[d][1–3]triazin-4(3H)-one, 7-chloro-3-(3-((4,5-dihydrothiazol-2-yl)thio)propyl)benzo[d][1–3]triazin-4(3H)-one exhibited good control efficacy against the cucumber root-knot nematode disease caused by Meloidogyne incognita at the concentration of 10.0 mg L?1 in vivo. Compound 7-chloro-3-(3-((4,5-dihydrothiazol-2-yl)thio)propyl)benzo[d][1–3]triazin-4(3H)-one showed excellent nematicidal activity with inhibition 68.3% at a concentration of 1.0 mg L?1. It suggested that the structure of 1,2,3-benzotriazin-4-one containing 4,5-dihydro-thiazole-2-thiol could be optimized further.

Fluorescent biaryl uracils with C5-dihydro- And quinazolinone heterocyclic appendages in PNA

There has been much effort to exploit fluorescence techniques in the detection of nucleic acids. Canonical nucleic acids are essentially nonfluorescent; however, the modification of the nucleobase has proved to be a fruitful way to engender fluorescence. Much of the chemistry used to prepare modified nucleobases relies on expensive transition metal catalysts. In this work, we describe the synthesis of biaryl quinazolinone-uracil nucleobase analogs prepared by the condensation of anthranilamide derivatives and 5-formyluracil using inexpensive copper salts. A selection of modified nucleobases were prepared, and the effect of methoxy- or nitro- group substitution on the photophysical properties was examined. Both the dihydroquinazolinone and quinazolinone modified uracils have much larger molar absorptivity (~4-8×) than natural uracil and produce modest blue fluorescence. The quinazolinone-modified uracils display higher quantum yields than the corresponding dihydroquinazolinones and also show temperature and viscosity dependent emission consistent with molecular rotor behavior. Peptide nucleic acid (PNA) monomers possessing quinazolinone modified uracils were prepared and incorporated into oligomers. In the sequence context examined, the nitro-substituted, methoxy-substituted and unmodified quinazolinone inserts resulted in a stabilization (?Tm = +4.0/insert; +2.0/insert; +1.0/insert, respectively) relative to control PNA sequence upon hybridization to complementary DNA. All three derivatives responded to hybridization by the “turn-on” of fluorescence intensity by ca. 3-to-4 fold and may find use as probes for complementary DNA sequences.

Synthesis and nematicidal evaluation of 1,2,3-benzotriazin-4-one derivatives containing piperazine as linker against Meloidogyne incognita

To explore new skeleton with nematicidal activity, a series of novel 1,2,3-benzotriazin-4-one derivatives containing piperazine as linker were synthesized and varied fragments were also introduced to increase structure diversity of the new skeleton. Their inhibitory activities in vivo were evaluated against Meloidogyne incognita. The newly prepared compounds A6, A8, A21, A28 and A38 exhibited more than 50% inhibition at the concentration of 20 mg/L. Especially compound A6 displayed 71.4% inhibition against Meloidogyne incognita at the concentration of 20 mg/L. The nematicidal activities varied significantly depending on the types and positions of the substituents, which provided guidance for further structure modification.

Oxidative ring-opening of isatins for the synthesis of 2-aminobenzamides and 2-aminobenzoates

An efficient and practical isatin-based oxidative domino protocol has been developed for the facile synthesis of 2-aminobenzamides and 2-aminobenzoates. The robust nature of this reaction system is reflected by accessible starting materials, room temperature and high-yield gram-scale synthesis.

Anti-inflammatory agents

Disclosed are novel compounds that are useful in regulating the expression of interleukin-6 (IL-6) and/or vascular cell adhesion molecule-1 (VCAM-1), and their use in the treatment and/or prevention of cardiovascular and inflammatory diseases and related disease states, such as, for example, atherosclerosis, asthma, arthritis, cancer, multiple sclerosis, psoriasis, and inflammatory bowel diseases, and autoimmune disease(s). Also, disclosed are compositions comprising the novel compounds, as well as methods for their preparation.

Synthesis and Nematicidal Activities of 1,2,3-Benzotriazin-4-one Derivatives against Meloidogyne incognita

A series of novel 1,2,3-benzotriazin-4-one derivatives were synthesized by the reaction of 3-bromoalkyl-1,2,3-benzotriazin-4-ones with potassium salt of 2-cyanoimino-4-oxothiazolidine in the presence of potassium iodide. Nematicidal assays in vivo showed that some of them exhibited good control efficacy against the cucumber root-knot nematode disease caused by Meloidogyne incognita, up to 100% at the concentration of 10.0 mg L-1, which indicated that 1,2,3-benzotriazin-4-one derivatives might be potential for novel promising nematicides. The nematicidal activity was influenced by the combination of substituent type, substituted position, and linker length in the molecule. The inhibition rate data at the concentrations of 5.0 and 1.0 mg L-1 for the compounds with high inhibitory activities were also provided. When tested in vitro, none of them showed direct inhibition against M. incognita. The investigation of a significant difference between in vivo and in vitro data is in progress.

BIARYL DERIVATIVES AS BROMODOMAIN INHIBITORS

The present disclosure relates to compounds, which are useful for inhibition of BET protein function by binding to bromodomains, and their use in therapy.

TREATMENT OF DISEASES BY EPIGENETIC REGULATION

The present disclosure provides non-naturally occurring polyphenol compounds that inhibit the bromodomain and extra terminal domain (BET) proteins. The disclosed compositions and methods can be used for treatment and prevention of diseases or disorders that are susceptible to administration of a BET inhibitor.

TREATMENT OF DISEASES BY EPIGENETIC REGULATION

The present disclosure provides non-naturally occurring polyphenol compounds that inhibit the bromodomain and extra terminal domain (BET) proteins. The disclosed compositions and methods can be used for treatment and prevention of diseases or disorders that are susceptible to administration of a BET inhibitor.