2-Methyl-4-chloro-6-bromophenol

Base Information

• Chemical Name: 2-Methyl-4-chloro-6-bromophenol
• CAS No.: 54852-68-5
• Molecular Formula: C7H6BrClO
• Molecular Weight: 221.481
• Hs Code.: 2908199090
• Mol file: 54852-68-5.mol

Synonyms:2-Bromo-4-chloro-6-methylphenol;2-Methyl-4-chloro-6-bromophenol

Chemical Property of 2-Methyl-4-chloro-6-bromophenol

Chemical Property:

• Melting Point: 51-52 °C(Solv: ligroine (8032-32-4))
• Boiling Point: 247.0±35.0 °C(Predicted)
• PKA: 8.34±0.23(Predicted)
• PSA: 20.23000
• Density: 1.674±0.06 g/cm3(Predicted)
• LogP: 3.11650
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

2-Bromo-4-chloro-6-methylphenol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Methyl-4-chloro-6-bromophenol

There total 4 articles about 2-Methyl-4-chloro-6-bromophenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

2-methyl-4-chlorophenol (1570-64-5) → 3-bromo-5-chloro-2-hydroxybenzylidene (54852-68-5)

Guidance literature:

With poly(4-vinylpyridinium bromochromate); In acetonitrile; at 20 ℃; for 0.283333h; regioselective reaction;

DOI:10.1007/s00706-012-0779-4

Reference yield: 78.0%

2-methyl-4-chlorophenol (1570-64-5) + diethylazodicarboxylate (1972-28-7,218603-74-8) → diethyl hydrazodicarboxylate (4114-28-7) + 3-bromo-5-chloro-2-hydroxybenzylidene (54852-68-5)

Guidance literature:

With ZrBr₄; In dichloromethane; at 0 ℃; for 1.5h;

DOI:10.1016/j.tetlet.2008.01.072

Reference yield: 74.0%

2-methyl-4-chlorophenol (1570-64-5) + di-isopropyl azodicarboxylate (2446-83-5) → bis(1-methylethyl) 1,2-hydrazinedicarboxylate (19740-72-8) + 3-bromo-5-chloro-2-hydroxybenzylidene (54852-68-5)

Guidance literature:

With ZrBr₄; In dichloromethane; at 0 - 20 ℃; for 1.5h;

DOI:10.1016/j.tetlet.2008.01.072

upstream raw materials:

2-methyl-4-chlorophenol

di-isopropyl azodicarboxylate

diethylazodicarboxylate

Downstream raw materials:

2-bromo-4-chloro-6-methylphenyl 2-propenyl ether

Refernces

• 1、 Albadi, Jalal,Tajik, Hassan,Keshavarz, Mosadegh,Abedini, Masoumeh. "Poly(4-vinylpyridinium bromochromate): An efficient reagent for bromination of aromatic compounds". . p. 179 - 181. Retrieved 2013/07/27.
• 2、 Barluenga, Jose,Fananas, Francisco J.,Sanz, Roberto,Marcos, Cesar. "Intramolecular carbolithiation of allyl o-lithioaryl ethers: A new enantioselective synthesis of functionalized 2,3-dihydrobenzofurans". . p. 5397 - 5407. Retrieved 2007/10/03.