Chemical Property of 1-(5-(2,3-Dichlorophenylthio)-4-nitrothiophen-2-yl)ethanone
Chemical Property:
- Boiling Point:452.4±45.0 °C(Predicted)
- PSA：116.43000
- Density:1.60±0.1 g/cm3(Predicted)
- LogP:5.84010
- Storage Temp.:2-8°C
- Solubility.:DMSO: soluble10mg/mL, clear
- XLogP3:5.1
- Hydrogen Bond Donor Count:0
- Hydrogen Bond Acceptor Count:5
- Rotatable Bond Count:3
- Exact Mass:346.9244408
- Heavy Atom Count:20
- Complexity:393
- Purity/Quality:
-
99%, *data from raw suppliers
P005091 *data from reagent suppliers
Safty Information:
- Pictogram(s):
T
- Hazard Codes:T
- Statements:
25
- Safety Statements:
45
- MSDS Files:
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SDS file from LookChem
Useful:
- Canonical SMILES:CC(=O)C1=CC(=C(S1)SC2=C(C(=CC=C2)Cl)Cl)[N+](=O)[O-]
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Description
P5091 (882257-11-6) is a selective inhibitor of the ubiquitin-specific protease USP7 ( IC50=4.2 μM).1,2 Induces apoptosis in multiple myeloma cells and overcomes bortezomib resistance.1?P5091 displays antiangiogenic activity in vivo.2?Cell permeable
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Uses
P005091 is a selective dual inhibitor of the cancer-related deubiquitylating proteases USP7 and USP47. P5091 has been used:as a ubiquitin specific peptidase 47 (USP47) inhibitor in 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay to evaluate the cellular viability of MCF-10A cellsas a USP7 inhibitor to study the regulatory role for USP7 on inflammasome activationas USP7 inhibitor in drug susceptibility assays to study its effect on bone marrow?resident tumor cells (BMRTCs)/ circulating tumor cells (CTCs)
