42456-75-7Relevant articles and documents
Mechanism of action of 5-nitrothiophenes against mycobacterium tuberculosis
Hartkoorn, Ruben C.,Ryabova, Olga B.,Chiarelli, Laurent R.,Riccardi, GioVanna,Makarov, Vadim,Makarov, Stewart T.
, p. 2944 - 2947 (2014)
On using the streptomycin-starved 18b strain as a model for nonreplicating Mycobacterium tuberculosis, we identified a 5-nitrothiophene compound as highly active but not cytotoxic. Mutants resistant to 5-nitrothiophenes were found be cross-resistant to the nitroimidazole PA-824 and unable to produce the F420 cofactor. Furthermore, 5-nitrothiophenes were shown to be activated by the F420-dependent nitroreductase Ddn and to release nitric oxide, a mechanism of action identical to that described for nitroimidazoles. Copyright
Selective oxidations of activated alcohols in water at room temperature
Lipshutz,Hageman,Fennewald,Linstadt,Slack,Voigtritter
supporting information, p. 11378 - 11381 (2014/11/08)
Allylic and benzylic alcohols can be selectively oxidized to their corresponding aldehydes or ketones in water containing nanoreactors composed of the designer surfactant TPGS-750-M. The oxidation relies on catalytic amounts of CuBr, bpy, and TEMPO, with N-methyl-imidazole; air is the stoichiometric oxidant. the Partner Organisations 2014.
ANTI-NEOPLASTIC COMPOUNDS, COMPOSITIONS AND METHODS
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Page/Page column 26, (2010/11/03)
Disclosed are novel compounds which are useful as therapeutics, especially in anti-neoplastic therapy and in other therapeutic regimes where cysteine protease inhibition is implicated.