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42456-75-7

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42456-75-7 Usage

General Description

1-(5-CHLORO-4-NITRO-2-THIENYL)ETHAN-1-ONE, also known as Clonitrothiofentanyl, is a synthetic opioid that is closely related to fentanyl. It is a potent analgesic and has a high potential for abuse and addiction. The chemical structure of Clonitrothiofentanyl includes a thiophene ring with a chlorine and nitro group attached, as well as an ethanone moiety. It is classified as a controlled substance and is not approved for medical use. Clonitrothiofentanyl is considered to be extremely dangerous and has been associated with numerous overdose deaths. Its production, distribution, and use are strictly regulated in many countries.

Check Digit Verification of cas no

The CAS Registry Mumber 42456-75-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 4,2,4,5 and 6 respectively; the second part has 2 digits, 7 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 42456-75:
(7*4)+(6*2)+(5*4)+(4*5)+(3*6)+(2*7)+(1*5)=117
117 % 10 = 7
So 42456-75-7 is a valid CAS Registry Number.
InChI:InChI=1/C6H4ClNO3S/c1-3(9)5-2-4(8(10)11)6(7)12-5/h2H,1H3

42456-75-7Upstream product

42456-75-7Relevant articles and documents

Mechanism of action of 5-nitrothiophenes against mycobacterium tuberculosis

Hartkoorn, Ruben C.,Ryabova, Olga B.,Chiarelli, Laurent R.,Riccardi, GioVanna,Makarov, Vadim,Makarov, Stewart T.

, p. 2944 - 2947 (2014)

On using the streptomycin-starved 18b strain as a model for nonreplicating Mycobacterium tuberculosis, we identified a 5-nitrothiophene compound as highly active but not cytotoxic. Mutants resistant to 5-nitrothiophenes were found be cross-resistant to the nitroimidazole PA-824 and unable to produce the F420 cofactor. Furthermore, 5-nitrothiophenes were shown to be activated by the F420-dependent nitroreductase Ddn and to release nitric oxide, a mechanism of action identical to that described for nitroimidazoles. Copyright

Selective oxidations of activated alcohols in water at room temperature

Lipshutz,Hageman,Fennewald,Linstadt,Slack,Voigtritter

supporting information, p. 11378 - 11381 (2014/11/08)

Allylic and benzylic alcohols can be selectively oxidized to their corresponding aldehydes or ketones in water containing nanoreactors composed of the designer surfactant TPGS-750-M. The oxidation relies on catalytic amounts of CuBr, bpy, and TEMPO, with N-methyl-imidazole; air is the stoichiometric oxidant. the Partner Organisations 2014.

ANTI-NEOPLASTIC COMPOUNDS, COMPOSITIONS AND METHODS

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Page/Page column 26, (2010/11/03)

Disclosed are novel compounds which are useful as therapeutics, especially in anti-neoplastic therapy and in other therapeutic regimes where cysteine protease inhibition is implicated.

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