(E)-2-(4-(cyclopropylsulfonyl)phenyl)-3-(tetrahydro-2H-pyran-4-yl)acrylic acid

Base Information

Chemical Name:(E)-2-(4-(cyclopropylsulfonyl)phenyl)-3-(tetrahydro-2H-pyran-4-yl)acrylic acid
CAS No.:745052-98-6
Molecular Formula:C17H20O5S
Molecular Weight:336.409
Hs Code.:2932999099
Mol file:745052-98-6.mol

Synonyms:(2E)-2-[4-(Cyclopropylsulfonyl)phenyl]-3-(tetrahydro-2H-pyran-4-yl)prop-2-enoic acid; (E)-2-[4-(Cyclopropylsulfonyl)phenyl]-3-(tetrahydropyran-4-yl)-2-propenoic acid

Suppliers and Price of (E)-2-(4-(cyclopropylsulfonyl)phenyl)-3-(tetrahydro-2H-pyran-4-yl)acrylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
(E)-2-(4-(Cyclopropylsulfonyl)phenyl)-3-(tetrahydro-2H-pyran-4-yl)acrylicacid 95+%
1g
$ 918.00

Chemenu
(E)-2-(4-(cyclopropylsulfonyl)phenyl)-3-(tetrahydro-2H-pyran-4-yl)acrylicacid 95%
1g
$ 866.00

Alichem
(E)-2-(4-(Cyclopropylsulfonyl)phenyl)-3-(tetrahydro-2h-pyran-4-yl)acrylicacid
1g
$ 1023.75

Total 5 raw suppliers

Chemical Property of (E)-2-(4-(cyclopropylsulfonyl)phenyl)-3-(tetrahydro-2H-pyran-4-yl)acrylic acid

Chemical Property:

Melting Point:93-95℃
PSA：89.05000
Density:1.394
LogP:3.59810

Purity/Quality:

98%,99%, ^*data from raw suppliers

(E)-2-(4-(Cyclopropylsulfonyl)phenyl)-3-(tetrahydro-2H-pyran-4-yl)acrylicacid 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of (E)-2-(4-(cyclopropylsulfonyl)phenyl)-3-(tetrahydro-2H-pyran-4-yl)acrylic acid

There total 7 articles about (E)-2-(4-(cyclopropylsulfonyl)phenyl)-3-(tetrahydro-2H-pyran-4-yl)acrylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

: 876063-40-0
(4-cyclopropylsulfonylphenyl)-2-oxo-acetic acid ethyl ester

: 745052-98-6
(E)-2-(4-(cyclopropylsulfonyl)phenyl)-3-(tetrahydro-2H-pyran-4-yl)acrylic acid

Guidance literature:: triphenyl((tetrahydro-2H-pyran-4-yl)methyl)phosphonium iodide; With lithium hexamethyldisilazane; In tetrahydrofuran; at -5 - 15 ℃; for 2.5h;

(4-cyclopropylsulfonylphenyl)-2-oxo-acetic acid ethyl ester; In tetrahydrofuran; at 0 - 25 ℃; for 17h;

With hydrogenchloride; methanol; sodium hydroxide; water; more than 3 stages;

Reference yield: 41.0%

: 745052-92-0
triphenyl((tetrahydro-2H-pyran-4-yl)methyl)phosphonium iodide

: 876063-40-0
(4-cyclopropylsulfonylphenyl)-2-oxo-acetic acid ethyl ester

: 745052-98-6
(E)-2-(4-(cyclopropylsulfonyl)phenyl)-3-(tetrahydro-2H-pyran-4-yl)acrylic acid

Guidance literature:: triphenyl((tetrahydro-2H-pyran-4-yl)methyl)phosphonium iodide; With lithium hexamethyldisilazane; In tetrahydrofuran; at -5 - 15 ℃; for 2.5h;

(4-cyclopropylsulfonylphenyl)-2-oxo-acetic acid ethyl ester; In tetrahydrofuran; at 0 - 25 ℃; for 17h;

With hydrogenchloride; methanol; sodium hydroxide; water; more than 3 stages;

Reference yield:

: ethyl (E)-2-(4-cyclopropylsulfonyl-phenyl)-3-(tetrahydropyran-4-yl)acrylate

: 745052-98-6
(E)-2-(4-(cyclopropylsulfonyl)phenyl)-3-(tetrahydro-2H-pyran-4-yl)acrylic acid

Guidance literature:: ethyl (E)-2-(4-cyclopropylsulfonyl-phenyl)-3-(tetrahydropyran-4-yl)acrylate; With methanol; sodium hydroxide; water; at 65 - 67 ℃; for 4h;

With hydrogenchloride; water; In tert-butyl methyl ether;